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DEXA for Project: NIH-0824
Test Description: Mice were anesthetized by intraperitoneal injection of Avertin (1.25% 2,2,2,-tribromoethanol, 20 ml/kg body weight ), measured body length and weight, and then placed in a prone position on the platform of the PIXImusTM Densitometer (Lunar Inc.) for a DEXA scan. Using a Lunar PIXImus software, the Bone mineral density (BMD) and fat composition (% fat) and total tissue mass (TTM) were determined in the regions of interest (ROI, i.e., whole body, vertebrae, and both femurs).


Results

  BMD = Bone Mineral Density (g/cm2);
  BMC = Bone Mineral Content (g);
  LBM = Lean Body Mass (g);
  BMC / LBM = BMC / LBM (mg/g); 		  FAT(%) = % of Body FAT;
  FAT(g) = TTM X FAT(%)/100;
  TTM = Total Tissue Mass (g);
  vBMD = Volumetric BMD (mg/cm3)

MALE DATA




FEMALE DATA



DEXA Combined Gender Score
Parameter Score
Body BMD  97.1%
Body vBMD  97.1%
Body BMC/LBM  97.5%
Femur BMD  102.0%
Vertebral BMD  97.1%
Total Tissue Mass  101.5%
Body LBM  100.6%
Body % Fat  105.6%
Body Fat Content  107.2%
The Combined Gender Score provides the average ration of Hom to WT values combining
males and females, with a correction factor for the number of mice in each group. No score
is generated if there are fewer than 4 HOM mice or fewer than 3 WT mice


DEXA Analysis: Male
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
M-62wt0.04790.455426.4119.4220.8321.8715.530.05720.07175000
M-94wt0.06290.671836.1320.6228.0123.9919.240.07450.09000000
M-71het0.04740.486127.4618.3821.9322.1714.810.05590.06990000
M-82het0.05430.580735.9421.1327.7720.9116.610.05920.08355001
M-72hom0.0510.510729.7421.5922.8122.3916.120.05590.07970000
M-73hom0.0520.525330.6718.7424.421.5316.360.05910.07865000
M-80hom0.04660.478325.0118.3219.9523.9814.540.05730.07150000
M-81hom0.05830.638530.6218.6124.2826.2917.610.06890.09810000

DEXA Analysis: Female
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
F-118wt0.0470.463920.8714.3617.4126.6514.970.06090.06375000
F-77wt0.05530.523922.9919.0918.0828.9817.970.06690.08300000
F-108het0.04560.396722.3419.0217.6922.4215.460.04930.06950000
F-85het0.04790.421325.1724.0518.722.5416.160.05640.06885000
F-109hom0.05140.493923.2720.0918.127.2916.580.05430.07705000
F-117hom0.05360.568125.5712.2521.8725.9816.460.07220.07820000
F-84hom0.04780.442623.1718.318.4923.9415.720.05690.07145000
F-86hom0.05270.45424.7626.117.8425.4417.950.0720.07475000




  DEXA Analysis data        Export Data to Spreadsheet
Mouse
Label 		Genotype Age (days) Site BMD BMC Length Weight FAT TTM
M-71 het 113 T-Animal Total 0.0474 0.4861 10.0 29.1 18.38 27.46
M-71 het 113 R-V 0.0559 0.0254 10.0 29.1 10.62 0.86
M-71 het 113 R-FL 0.0726 0.0273 10.0 29.1 21.54 0.62
M-71 het 113 R-FR 0.0672 0.0277 10.0 29.1 13.03 0.58
M-82 het 113 T-Animal Total 0.0543 0.5807 10.7 36.96 21.13 35.94
M-82 het 113 R-V 0.0592 0.0275 10.7 36.96 15.91 1.09
M-82 het 113 R-FL 0.0837 0.0355 10.7 36.96 28.15 0.84
M-82 het 113 R-FR 0.0834 0.0377 10.7 36.96 14.12 0.69
F-85 het 113 T-Animal Total 0.0479 0.4213 10.0 26.63 24.05 25.17
F-85 het 113 R-FR 0.0656 0.0243 10.0 26.63 22.82 0.48
F-85 het 113 R-V 0.0564 0.0249 10.0 26.63 10.57 0.91
F-85 het 113 R-FL 0.0721 0.0256 10.0 26.63 25.4 0.52
F-108 het 113 T-Animal Total 0.0456 0.3967 9.5 24.31 19.02 22.34
F-108 het 113 R-V 0.0493 0.022 9.5 24.31 6.04 0.85
F-108 het 113 R-FR 0.0676 0.0247 9.5 24.31 18.81 0.47
F-108 het 113 R-FL 0.0714 0.0244 9.5 24.31 20.51 0.52
M-72 hom 113 T-Animal Total 0.051 0.5107 10.4 31.06 21.59 29.74
M-72 hom 113 R-FR 0.0762 0.0294 10.4 31.06 12.8 0.57
M-72 hom 113 R-V 0.0559 0.025 10.4 31.06 14.72 0.9
M-72 hom 113 R-FL 0.0832 0.027 10.4 31.06 20.67 0.51
M-73 hom 113 T-Animal Total 0.052 0.5253 10.3 32.78 18.74 30.67
M-73 hom 113 R-V 0.0591 0.0272 10.3 32.78 9.52 0.96
M-73 hom 113 R-FL 0.079 0.0293 10.3 32.78 21.71 0.59
M-73 hom 113 R-FR 0.0783 0.0331 10.3 32.78 14.2 0.62
M-80 hom 113 T-Animal Total 0.0466 0.4783 10.0 26.29 18.32 25.01
M-80 hom 113 R-V 0.0573 0.0269 10.0 26.29 6.13 0.87
M-80 hom 113 R-FL 0.0742 0.0254 10.0 26.29 21.72 0.5
M-80 hom 113 R-FR 0.0688 0.0305 10.0 26.29 11.91 0.61
M-81 hom 113 T-Animal Total 0.0583 0.6385 10.3 32.32 18.61 30.62
M-81 hom 113 R-V 0.0689 0.032 10.3 32.32 10.84 0.96
M-81 hom 113 R-FL 0.1033 0.0425 10.3 32.32 17.85 0.64
M-81 hom 113 R-FR 0.0929 0.041 10.3 32.32 11.9 0.62
F-84 hom 113 T-Animal Total 0.0478 0.4426 9.8 24.87 18.3 23.17
F-84 hom 113 R-V 0.0569 0.0258 9.8 24.87 9.3 0.87
F-84 hom 113 R-FL 0.0733 0.0262 9.8 24.87 19.31 0.5
F-84 hom 113 R-FR 0.0696 0.0284 9.8 24.87 18.01 0.53
F-86 hom 113 T-Animal Total 0.0527 0.454 9.8 25.71 26.1 24.76
F-86 hom 113 R-V 0.072 0.0307 9.8 25.71 19.02 0.95
F-86 hom 113 R-FL 0.0777 0.0262 9.8 25.71 25.32 0.5
F-86 hom 113 R-FR 0.0718 0.0251 9.8 25.71 24.29 0.47
F-109 hom 113 T-Animal Total 0.0514 0.4939 9.7 24.72 20.09 23.27
F-109 hom 113 R-V 0.0543 0.025 9.7 24.72 10.92 0.96
F-109 hom 113 R-FR 0.0753 0.031 9.7 24.72 16.83 0.5
F-109 hom 113 R-FL 0.0788 0.0334 9.7 24.72 13.14 0.49
F-117 hom 113 T-Animal Total 0.0536 0.5681 10.0 27.71 12.25 25.57
F-117 hom 113 R-V 0.0722 0.0348 10.0 27.71 4.7 0.92
F-117 hom 113 R-FR 0.0761 0.0356 10.0 27.71 12.97 0.58
F-117 hom 113 R-FL 0.0803 0.0329 10.0 27.71 12.67 0.59
M-62 wt 115 T-Animal Total 0.0479 0.4554 9.8 27.7 19.42 26.41
M-62 wt 115 R-V 0.0572 0.0265 9.8 27.7 9.15 0.84
M-62 wt 115 R-FL 0.076 0.0252 9.8 27.7 20.87 0.59
M-62 wt 115 R-FR 0.0675 0.025 9.8 27.7 13.41 0.52
F-77 wt 113 T-Animal Total 0.0553 0.5239 9.8 24.86 19.09 22.99
F-77 wt 113 R-V 0.0669 0.0301 9.8 24.86 6.61 0.9
F-77 wt 113 R-FL 0.0862 0.0316 9.8 24.86 20.59 0.51
F-77 wt 113 R-FR 0.0798 0.0321 9.8 24.86 19.17 0.55
M-94 wt 113 T-Animal Total 0.0629 0.6718 10.6 38.08 20.62 36.13
M-94 wt 113 R-FR 0.0876 0.045 10.6 38.08 12.98 0.79
M-94 wt 113 R-FL 0.0924 0.0469 10.6 38.08 22.05 1.04
M-94 wt 113 R-V 0.0745 0.0356 10.6 38.08 15.7 1.16
F-118 wt 113 T-Animal Total 0.047 0.4639 9.5 22.81 14.36 20.87
F-118 wt 113 R-V 0.0609 0.0289 9.5 22.81 3.45 0.88
F-118 wt 113 R-FL 0.0635 0.0242 9.5 22.81 14.7 0.51
F-118 wt 113 R-FR 0.064 0.026 9.5 22.81 15.27 0.48
 


Copyright 2005 by Lexicon Genetics Incorporated
Lexicon Phenotypic Analysis software version 05.05.00.05