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Test Description: Groups of naïve mice are trained in conditioning chambers (Med-Associates, St. Albans, Vermont) that have stainless steel rod floors through which foot shocks are delivered. For cued trace fear conditioning mice are placed in training context and left undisturbed for habituation purposes for 3 min. Then a conditioned stimulus (CS: 15 sec duration, 85 dB 3kHz) generated by tone is delivered, followed by a trace period of 10 sec and the unconditioned stimulus (US: foot shock, 2 sec, 0.35 mA). Mice are presented with 3 trials with inter-trial interval (ITI) 2 min and returned to the home cage 1 minute after the final shock.


Results








  Trace Aversive Conditioning data        Export Data to Spreadsheet
Mouse Label Genotype Age (days) Pre-CS Freezing Post-CS Freezing Difference CS Freezing
M-161 hom 87 0.0 13.33 13.33
F-163 hom 87 4.44 2.22 -2.22
M-167 hom 87 0.0 4.44 4.44
M-173 hom 87 6.67 7.78 1.11
M-182 hom 87 21.11 5.56 -15.55
F-200 hom 86 0.0 8.89 8.89
F-211 hom 86 41.11 87.78 46.67
F-223 hom 85 8.89 10.0 1.11
M-165 wt 87 4.44 10.0 5.56
M-179 wt 87 16.67 63.33 46.66
F-183 wt 87 3.33 8.89 5.56
F-198 wt 86 12.22 80.0 67.78
M-203 wt 86 5.56 7.78 2.22
F-216 wt 86 6.67 44.44 37.77
F-225 wt 85 5.56 14.44 8.88
M-231 wt 85 18.89 27.78 8.89
 


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Lexicon Phenotypic Analysis software version 05.05.00.05