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Test Description: Bacterial lipopolysaccharide (LPS) is an endotoxin, a potent inducer of the acute phase response and systemic inflammation. The mice will:
  • Be injected intraperitoneally (i.p.) with a sublethal dose of LPS in 200 µL sterile saline using a 26 gauge needle.
  • The dose will be based on the average weight of the mice tested at 1 g/g body weight 3 hours after injection, a 100ul blood sample will be taken and analyzed for the presence of TNFα, MCP-1, and IL-6 on the FACSCalibur.


Results





  Acute Phase Response data for Project: NIH-0778 - Results        Export Data to Spreadsheet
Mouse Label Genotype Age (days) TNF-a MCP-1 IL-6
M-161 hom 113 1326.0 60256.1 34230.6
M-167 hom 113 1206.2 50083.0 44720.3
M-173 hom 113 1149.3 49125.4 41848.0
M-182 hom 113 845.3 44244.1 26745.9
M-165 wt 113 591.3 18789.4 2520.0
M-179 wt 113 865.1 38974.1 32264.9
M-203 wt 112 968.1 33520.9 29136.4
M-231 wt 111 2491.3 70916.6 48570.7
 


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Lexicon Phenotypic Analysis software version 05.05.00.05