Help



Test Description: Mice were anesthetized by intraperitoneal injection of Avertin (1.25% 2,2,2,-tribromoethanol, 20 ml/kg body weight ), measured body length and weight, and then placed in a prone position on the platform of the PIXImusTM Densitometer (Lunar Inc.) for a DEXA scan. Using a Lunar PIXImus software, the Bone mineral density (BMD) and fat composition (% fat) and total tissue mass (TTM) were determined in the regions of interest (ROI, i.e., whole body, vertebrae, and both femurs).


Results

  BMD = Bone Mineral Density (g/cm2);
  BMC = Bone Mineral Content (g);
  LBM = Lean Body Mass (g);
  BMC / LBM = BMC / LBM (mg/g);
  FAT(%) = % of Body FAT;
  FAT(g) = TTM X FAT(%)/100;
  TTM = Total Tissue Mass (g);
  vBMD = Volumetric BMD (mg/cm3)

MALE DATA





FEMALE DATA



DEXA Combined Gender Score
Parameter Score
Body BMD  99.0%
Body vBMD  99.5%
Body BMC/LBM  102.5%
Femur BMD  94.2%
Vertebral BMD  99.5%
Total Tissue Mass  91.3%
Body LBM  95.7%
Body % Fat  85.6%
Body Fat Content  76.9%
The Combined Gender Score provides the average ration of Hom to WT values combining
males and females, with a correction factor for the number of mice in each group. No score
is generated if there are fewer than 4 HOM mice or fewer than 3 WT mice


DEXA Analysis: Male
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
M-165wt0.04820.430524.1719.7318.9722.6916.120.04610.07100000
M-179wt0.04970.479431.3725.7622.8121.0216.010.05380.08270000
M-157het0.04960.483229.5520.123.1320.8915.880.05730.07325000
M-174het0.04840.468627.8817.2822.5920.7415.560.04670.07520000
M-161hom0.05260.555727.3514.5822.8124.3716.180.05780.07700001
M-167hom0.04850.462525.4715.9320.9522.0815.70.05540.07240000
M-173hom0.05160.502129.4817.3423.8721.0416.530.05450.07885000
M-182hom0.04870.421325.0219.9819.621.516.560.04990.07325000

DEXA Analysis: Female
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
F-183wt0.04840.423325.7526.0518.6222.7416.370.06190.07290000
F-216wt0.04960.464124.4122.2218.5225.0616.210.05540.07185000
F-187het0.04970.46123.421.3817.9425.716.310.06290.07270000
F-240het0.04730.412426.328.2118.4722.3316.030.05450.06760000
F-163hom0.04890.434323.0525.016.8525.7716.40.06110.06770000
F-200hom0.0470.410920.6720.3616.0525.615.90.05330.06480000
F-211hom0.0430.336519.8924.4714.6922.9115.370.05210.06080000
F-223hom0.04740.413322.7323.5316.9724.3616.060.04980.06845000




  DEXA Analysis data        Export Data to Spreadsheet
Mouse
Label
Genotype Age (days) Site BMD BMC Length Weight FAT TTM
M-157 het 100 R-V 0.0573 0.0229 10.1 30.47 11.52 1.39
M-157 het 100 R-FL 0.0753 0.0291 10.1 30.47 25.62 0.75
M-157 het 100 R-FR 0.0712 0.0302 10.1 30.47 14.86 0.82
M-157 het 100 T-Animal Total 0.0496 0.4832 10.1 30.47 20.1 29.55
M-174 het 100 T-Animal Total 0.0484 0.4686 10.0 28.6 17.28 27.88
M-174 het 100 R-V 0.0467 0.0184 10.0 28.6 11.25 1.37
M-174 het 100 R-FL 0.0765 0.0303 10.0 28.6 20.44 0.82
M-174 het 100 R-FR 0.0739 0.0321 10.0 28.6 11.91 0.74
F-187 het 100 T-Animal Total 0.0497 0.461 9.4 23.95 21.38 23.4
F-187 het 100 R-V 0.0629 0.0242 9.4 23.95 11.18 1.24
F-187 het 100 R-FR 0.0701 0.028 9.4 23.95 19.69 0.64
F-187 het 100 R-FL 0.0753 0.0265 9.4 23.95 27.4 0.61
F-240 het 98 T-Animal Total 0.0473 0.4124 9.8 26.6 28.21 26.3
F-240 het 98 R-V 0.0545 0.0192 9.8 26.6 22.0 1.23
F-240 het 98 R-FR 0.0652 0.0275 9.8 26.6 29.86 0.84
F-240 het 98 R-FL 0.07 0.027 9.8 26.6 35.29 0.79
M-161 hom 100 T-Animal Total 0.0526 0.5557 10.2 28.9 14.58 27.35
M-161 hom 100 R-FR 0.0772 0.0407 10.2 28.9 12.02 0.84
M-161 hom 100 R-FL 0.0768 0.0345 10.2 28.9 14.81 0.8
M-161 hom 100 R-V 0.0578 0.0234 10.2 28.9 9.06 1.44
F-163 hom 100 T-Animal Total 0.0489 0.4343 9.3 23.84 25.0 23.05
F-163 hom 100 R-V 0.0611 0.0244 9.3 23.84 14.23 1.31
F-163 hom 100 R-FL 0.0701 0.0267 9.3 23.84 31.78 0.76
F-163 hom 100 R-FR 0.0653 0.0279 9.3 23.84 24.63 0.68
M-167 hom 100 T-Animal Total 0.0485 0.4625 9.6 26.38 15.93 25.47
M-167 hom 100 R-V 0.0554 0.0235 9.6 26.38 5.67 1.45
M-167 hom 100 R-FL 0.0742 0.0281 9.6 26.38 20.62 0.71
M-167 hom 100 R-FR 0.0706 0.0288 9.6 26.38 12.36 0.67
M-173 hom 100 T-Animal Total 0.0516 0.5021 10.1 30.61 17.34 29.48
M-173 hom 100 R-V 0.0545 0.0217 10.1 30.61 8.64 1.3
M-173 hom 100 R-FL 0.08 0.0339 10.1 30.61 19.28 0.79
M-173 hom 100 R-FR 0.0777 0.0357 10.1 30.61 12.02 0.73
M-182 hom 100 T-Animal Total 0.0487 0.4213 9.4 25.87 19.98 25.02
M-182 hom 100 R-V 0.0499 0.0171 9.4 25.87 9.19 1.23
M-182 hom 100 R-FL 0.0773 0.0271 9.4 25.87 25.68 0.68
M-182 hom 100 R-FR 0.0692 0.0256 9.4 25.87 23.16 0.71
F-200 hom 99 T-Animal Total 0.047 0.4109 8.8 21.51 20.36 20.67
F-200 hom 99 R-V 0.0533 0.0239 8.8 21.51 6.14 1.31
F-200 hom 99 R-FR 0.0639 0.0251 8.8 21.51 20.17 0.6
F-200 hom 99 R-FL 0.0657 0.0238 8.8 21.51 23.1 0.58
F-211 hom 99 T-Animal Total 0.043 0.3365 9.0 20.7 24.47 19.89
F-211 hom 99 R-V 0.0521 0.0175 9.0 20.7 13.72 1.08
F-211 hom 99 R-FR 0.0586 0.0208 9.0 20.7 25.05 0.54
F-211 hom 99 R-FL 0.063 0.0207 9.0 20.7 29.05 0.52
F-223 hom 98 T-Animal Total 0.0474 0.4133 9.5 23.77 23.53 22.73
F-223 hom 98 R-V 0.0498 0.0185 9.5 23.77 14.14 1.21
F-223 hom 98 R-FR 0.0655 0.0258 9.5 23.77 21.33 0.56
F-223 hom 98 R-FL 0.0714 0.0266 9.5 23.77 27.69 0.63
M-165 wt 100 T-Animal Total 0.0482 0.4305 9.5 24.55 19.73 24.17
M-165 wt 100 R-V 0.0461 0.0182 9.5 24.55 8.23 1.47
M-165 wt 100 R-FR 0.0662 0.0289 9.5 24.55 20.97 0.7
M-165 wt 100 R-FL 0.0758 0.0297 9.5 24.55 20.0 0.68
M-179 wt 100 T-Animal Total 0.0497 0.4794 10.0 32.05 25.76 31.37
M-179 wt 100 R-V 0.0538 0.0188 10.0 32.05 14.81 1.22
M-179 wt 100 R-FR 0.0782 0.0325 10.0 32.05 19.96 0.82
M-179 wt 100 R-FL 0.0872 0.0331 10.0 32.05 27.45 0.8
F-183 wt 100 T-Animal Total 0.0484 0.4233 9.4 26.18 26.05 25.75
F-183 wt 100 R-FR 0.071 0.0275 9.4 26.18 27.61 0.76
F-183 wt 100 R-V 0.0619 0.0268 9.4 26.18 12.76 1.5
F-183 wt 100 R-FL 0.0748 0.0275 9.4 26.18 31.66 0.7
F-216 wt 99 T-Animal Total 0.0496 0.4641 10.0 25.23 22.22 24.41
F-216 wt 99 R-V 0.0554 0.0237 10.0 25.23 12.52 1.32
F-216 wt 99 R-FL 0.0749 0.0289 10.0 25.23 28.04 0.65
F-216 wt 99 R-FR 0.0688 0.0298 10.0 25.23 21.0 0.67
 


Copyright 2005 by Lexicon Genetics Incorporated
Lexicon Phenotypic Analysis software version 05.05.00.05