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Acute Phase Response for Project: NIH-0719
Test Description: Bacterial lipopolysaccharide (LPS) is an endotoxin, a potent inducer of the acute phase response and systemic inflammation. The mice will:
  • Be injected intraperitoneally (i.p.) with a sublethal dose of LPS in 200 µL sterile saline using a 26 gauge needle.
  • The dose will be based on the average weight of the mice tested at 1 µg/g body weight 3 hours after injection, a 100ul blood sample will be taken and analyzed for the presence of TNFα, MCP-1, and IL-6 on the FACSCalibur.


Results





  Acute Phase Response data for Project: NIH-0719 - Results        Export Data to Spreadsheet
Mouse Label Genotype Age (days) TNF-a MCP-1 IL-6
M-78 hom 131 15328.3 33417.6 43501.7
M-91 hom 131 2005.7 42634.2 72033.1
M-100 hom 130 2018.2 31238.4 53856.7
M-105 hom 130 1956.4 52027.5 58033.1
M-68 wt 131 610.3 26763.5 11329.2
M-79 wt 131 2837.1 29877.7 96752.9
 


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