Inverted Screen for Project: NIH-0719 Test Description: A motor strength deficit is apparent when there is a 50% point difference between (-/-) or (+/-) mice and (+/+) mice for the fell down response. 0/8 or 1/8 (-/-) or (+/-) mice not climbing indicates impaired motor coordination. 7/8 or 8/8(-/-) or (+/-) mice climbing up indicates enhanced motor coordination.

Results Genotype Ratio Fell Down % Ratio Climbed Up % +/+ (n=4) 0/4 0 4/4 100 +/- (n=4) 0/4 0 4/4 100 -/- (n=8) 0/8 0 6/8 75 WT Population Fell Down 3.62 Climbed Up 60.04 *Red color coding indicates a notable difference.

Inverted Screen data for Project: NIH-0719 - Results        Mouse Label Genotype Age (days) Test Result Weight at Testing Comments F-73 het 91 Climbed Up 23.8 16 seconds. F-85 het 91 Climbed Up 24.4 20 seconds. F-95 het 91 Climbed Up 21.5 4 seconds. F-97 het 91 Climbed Up 23.5 17 seconds. M-67 hom 91 Did Not Climb 28.9 M-71 hom 91 Climbed Up 31.9 32 seconds. M-78 hom 91 Climbed Up 30.6 22 seconds. M-82 hom 91 Climbed Up 31.1 49 seconds. M-89 hom 91 Did Not Climb 27.9 M-91 hom 91 Climbed Up 30.0 13 seconds. M-100 hom 90 Climbed Up 29.3 42 seconds. M-105 hom 90 Climbed Up 34.2 14 seconds. M-68 wt 91 Climbed Up 27.3 34 seconds. F-75 wt 91 Climbed Up 22.1 15 seconds. M-79 wt 91 Climbed Up 27.8 45 seconds. F-86 wt 91 Climbed Up 23.3 38 seconds.

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Lexicon Phenotypic Analysis software version 05.05.00.05