Stress Induced Hyperthermia for Project: NIH-0129 Test Description: (SIH) is a measurement of autonomic hyperactivity induced by anxiety-provoking stimuli. The method involves taking two rectal body temperature measurements 10 minutes apart. SIH is determined by subtracting the basal body temperature (T1) from the stress-enhanced temperature (T2). The difference in delta values (T2 - T1 = deltaT) indicates the severity of autonomic hyperactivity or SIH. The rise in body temperature associated with SIH is a sign of anticipatory anxiety to the second rectal body temperature measurement. Lower deltaT values suggest decreased anxiety-like responses.

Results

Stress-Induced Hyperthermia Analysis data        Mouse Label Genotype Age (days) Stress Temperature Basal Temperature M-87 het 64 37.5 36.7 M-92 het 64 37.5 35.9 M-99 het 64 37.1 35.8 M-114 het 62 37.0 35.8 M-55 wt 66 36.3 35.1 M-69 wt 64 36.6 35.3 F-56 het 66 0.0 35.7 F-90 het 64 0.0 35.5 F-96 het 64 0.0 36.0 F-103 het 64 0.0 36.1 F-95 wt 64 0.0 35.0 F-105 wt 64 0.0 35.6

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Lexicon Phenotypic Analysis software version 05.05.00.05