Inverted Screen for Project: NIH-0129 Test Description: A motor strength deficit is apparent when there is a 50% point difference between (-/-) or (+/-) mice and (+/+) mice for the fell down response. 0/8 or 1/8 (-/-) or (+/-) mice not climbing indicates impaired motor coordination. 7/8 or 8/8(-/-) or (+/-) mice climbing up indicates enhanced motor coordination.

Results Genotype Ratio Fell Down % Ratio Climbed Up % +/+ (n=4) 1/4 25 3/4 75 +/- (n=8) 0/8 0 5/8 63 WT Population Fell Down 3.62 Climbed Up 60.04 *Red color coding indicates a notable difference.

Inverted Screen data for Project: NIH-0129 - Results        Mouse Label Genotype Age (days) Test Result Weight at Testing Comments F-56 het 83 Climbed Up 28.0 Animal climbed up in 12 seconds. M-87 het 81 Did Not Climb 34.6 F-90 het 81 Did Not Climb 25.2 M-92 het 81 Did Not Climb 35.3 F-96 het 81 Climbed Up 26.4 Animal climbed up in 4 seconds. M-99 het 81 Climbed Up 33.5 Animal climbed up in 15 seconds. F-103 het 81 Climbed Up 25.2 Animal climbed up in 8 seconds. M-114 het 79 Climbed Up 33.6 Animal climbed up in 38 seconds. M-55 wt 83 Fell Down 36.1 Animal fell off of screen in 34 seconds. M-69 wt 81 Climbed Up 31.3 Animal climbed up in 1 second. F-95 wt 81 Climbed Up 21.9 Animal climbed up in 35 seconds. F-105 wt 81 Climbed Up 22.2 Animal climbed up in 23 seconds.

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Lexicon Phenotypic Analysis software version 05.05.00.05