Inverted Screen for Project: NIH-0195 Test Description: A motor strength deficit is apparent when there is a 50% point difference between (-/-) or (+/-) mice and (+/+) mice for the fell down response. 0/8 or 1/8 (-/-) or (+/-) mice not climbing indicates impaired motor coordination. 7/8 or 8/8(-/-) or (+/-) mice climbing up indicates enhanced motor coordination.

Results Genotype Ratio Fell Down % Ratio Climbed Up % +/+ (n=4) 0/4 0 4/4 100 +/- (n=4) 0/4 0 2/4 50 -/- (n=9) 0/9 0 7/9 78 WT Population Fell Down 3.62 Climbed Up 60.04 *Red color coding indicates a notable difference.

Inverted Screen data for Project: NIH-0195 - Results        Mouse Label Genotype Age (days) Test Result Weight at Testing Comments F-49 het 101 Did Not Climb 24.8 F-50 het 86 Climbed Up 21.9 climbed up in 34 seconds M-83 het 86 Climbed Up 25.7 climbed up in 6 seconds M-108 het 85 Did Not Climb 30.0 F-51 hom 86 Did Not Climb 27.6 F-52 hom 86 Climbed Up 24.9 climbed up in 5 seconds F-53 hom 86 Climbed Up 28.3 climbed up in 14 seconds M-54 hom 86 Climbed Up 38.4 climbed up in 59 seconds F-63 hom 86 Climbed Up 25.3 climbed up in 59 seconds F-71 hom 86 Climbed Up 21.5 climbed up in 13 seconds F-99 hom 86 Climbed Up 24.1 climbed up in 7 seconds M-107 hom 85 Did Not Climb 31.4 M-110 hom 85 Climbed Up 29.4 climbed up in 5 seconds M-55 wt 86 Climbed Up 37.0 climbed up in 23 seconds F-77 wt 86 Climbed Up 22.0 climbed up in 50 seconds F-88 wt 86 Climbed Up 22.8 climbed up in 58 seconds M-109 wt 85 Climbed Up 30.0 climbed up in 14 seconds

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Lexicon Phenotypic Analysis software version 05.05.00.05