Functional Observational Battery |
Test Description: The FOB is a series of situations applied to the animal to determine gross sensory and motor deficits. A subset of tests from the Irwin neurological screen that evaluates gross neurological function is used. In general, short-duration, tactile, olfactory, and visual stimuli are applied to the animal to determine their ability to detect and respond normally. These simple tests take approximately 10 minutes and the mouse is returned to its home cage at the end of testing. |
BehaviorNew Category
| Genotype |
WildType (WT, +/+) | Heterozygote (Het, +/-,-/+) | Homozygote (Hom, -/-) |
n=4 | n=4 | n=9 |
"General health and Physical Condition | wt | het | hom |
Whiskers Absent | 1 (25%) | 1 (25%) | 3 (33%) |
Bald_Hair_Patches Present | 1 (25%) | 1 (25%) | 3 (33%) |
Piloerection Present | 0 (0%) | 0 (0%) | 0 (0%) |
Exophthalmus Present | 1 (25%) | 1 (25%) | 1 (11%) |
Palpebral_Closure Present | 0 (0%) | 0 (0%) | 0 (0%) |
Straub_Tail Present | 0 (0%) | 0 (0%) | 0 (0%) |
Curly_Kinked_Tail Present | 0 (0%) | 0 (0%) | 0 (0%) |
Kyphosis Present | 0 (0%) | 0 (0%) | 0 (0%) |
Lordosis Present | 0 (0%) | 0 (0%) | 0 (0%) |
Spontaneous Activity | wt | het | hom |
Exhibits Wild Running Behavior | 0 (0%) | 0 (0%) | 0 (0%) |
Exhibits Freezing Behavior | 0 (0%) | 0 (0%) | 0 (0%) |
Exhibits Sniffing Behavior | 0 (0%) | 0 (0%) | 0 (0%) |
Exhibits Licking Behavior | 0 (0%) | 0 (0%) | 0 (0%) |
Rearing Behavior Absent | 0 (0%) | 3 (75%) | 0 (0%) |
Exhibits Jumping Behavior | 0 (0%) | 0 (0%) | 0 (0%) |
Defication Absent | 0 (0%) | 1 (25%) | 0 (0%) |
Urination | 0 (0%) | 0 (0%) | 0 (0%) |
Does not Move All Around The Cage | 0 (0%) | 0 (0%) | 0 (0%) |
Head Bobbing Present | 0 (0%) | 0 (0%) | 0 (0%) |
Head Flicking Present | 0 (0%) | 0 (0%) | 0 (0%) |
Circling Present | 0 (0%) | 0 (0%) | 0 (0%) |
Waltzing Present | 0 (0%) | 0 (0%) | 0 (0%) |
Abnormal Gait Present | 0 (0%) | 0 (0%) | 0 (0%) |
Retropulsion Present | 0 (0%) | 0 (0%) | 0 (0%) |
Prancing Forelimbs Present | 0 (0%) | 0 (0%) | 0 (0%) |
Tail Suspension Response | wt | het | hom |
20 Second Tail Suspension Response - Normal Splay of Limbs | 4 (100%) | 4 (100%) | 9 (100%) |
20 Second Tail Suspension Response - Does Not Turn Up Sides | 0 (0%) | 0 (0%) | 0 (0%) |
20 Second Tail Suspension Response - Does Not Grab ipsilateral Leg | 0 (0%) | 0 (0%) | 0 (0%) |
20 Second Tail Suspension Response - Does Not Grab Contralateral Leg | 0 (0%) | 0 (0%) | 0 (0%) |
20 Second Tail Suspension Response - Hindpaw Clutch | 0 (0%) | 0 (0%) | 0 (0%) |
20 Second Tail Suspension Response - Forepaw Clutch | 0 (0%) | 0 (0%) | 0 (0%) |
20 Second Tail Suspension Response - Other Responses | 0 (0%) | 0 (0%) | 0 (0%) |
* Blue color coding is set for a threshold of 10% * Red color coding indicates het or hom value >= or <= 50% of the wildtype value.
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Functional Observation Battery Comments: |
- F-88(wt): Barbered whiskers. Bald patches around snout. Housed with F-52, F-71, F-63 and F-99. Slight exophthalmus.
- F-49(het): Slight exophthalmus.
Indiividually housed.
- M-83(het): Barbered whiskers. Bald patches around snout. Housed with M-78.
- F-52(hom): Barbered whiskers. Bald patches around snout. Housed with F-88, F-71, F-63 and F-99.
- F-71(hom): Barbered whiskers. Bald patches around snout. Housed with F-52, F-88, F-63 and F-99.
- F-99(hom): Barbered whiskers. Bald patches around snout. Housed with F-52, F-88, F-71 and F-63. Slight exophthalmus.
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