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DEXA for Project: NIH-0195
Test Description: Mice were anesthetized by intraperitoneal injection of Avertin (1.25% 2,2,2,-tribromoethanol, 20 ml/kg body weight ), measured body length and weight, and then placed in a prone position on the platform of the PIXImusTM Densitometer (Lunar Inc.) for a DEXA scan. Using a Lunar PIXImus software, the Bone mineral density (BMD) and fat composition (% fat) and total tissue mass (TTM) were determined in the regions of interest (ROI, i.e., whole body, vertebrae, and both femurs).


Results

  BMD = Bone Mineral Density (g/cm2);
  BMC = Bone Mineral Content (g);
  LBM = Lean Body Mass (g);
  BMC / LBM = BMC / LBM (mg/g); 		  FAT(%) = % of Body FAT;
  FAT(g) = TTM X FAT(%)/100;
  TTM = Total Tissue Mass (g);
  vBMD = Volumetric BMD (mg/cm3)

MALE DATA




FEMALE DATA



DEXA Combined Gender Score
Parameter Score
Body BMD  108.2%
Body vBMD  105.0%
Body BMC/LBM  103.4%
Femur BMD  108.3%
Vertebral BMD  105.0%
Total Tissue Mass  107.4%
Body LBM  110.7%
Body % Fat  88.9%
Body Fat Content  94.1%
The Combined Gender Score provides the average ration of Hom to WT values combining
males and females, with a correction factor for the number of mice in each group. No score
is generated if there are fewer than 4 HOM mice or fewer than 3 WT mice


DEXA Analysis: Male
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
M-109wt0.05050.540626.449.1523.4823.0215.440.06350.07785000
M-55wt0.06090.621334.9818.4527.922.2619.080.06890.09230000
M-108het0.05590.563930.5515.7425.1822.417.610.06060.08220001
M-83het0.04870.443225.4814.9321.2320.8716.140.05130.07060000
M-107hom0.05490.596229.9411.9325.7723.1316.670.06380.08745000
M-110hom0.0520.503929.1314.4624.4120.6416.70.0530.07490000
M-54hom0.0620.680237.1715.1930.8422.0518.730.07550.09590000

DEXA Analysis: Female
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
F-77wt0.04630.37522.021.6216.8722.2316.270.05680.06750000
F-88wt0.04960.49822.7319.9317.728.1315.650.05610.06955000
F-49het0.05090.458125.6621.519.6923.2716.970.05990.07045000
F-50het0.04940.476421.6814.8517.9826.4915.910.05970.07125000
F-51hom0.05470.518725.5918.9820.2125.6617.770.06510.07620000
F-52hom0.0530.57424.3314.5820.2128.416.10.06560.07655000
F-53hom0.05760.573526.6320.5120.5927.8518.260.08030.08630000
F-63hom0.05130.492624.9316.0120.4524.0916.550.06590.07265000
F-71hom0.05130.491621.5114.5517.8927.4816.570.05590.07475000
F-99hom0.05620.550423.617.119.0128.9517.960.07180.07715000




  DEXA Analysis data        Export Data to Spreadsheet
Mouse
Label 		Genotype Age (days) Site BMD BMC Length Weight FAT TTM
F-49 het 113 T-Animal Total 0.0509 0.4581 9.4 26.87 21.5 25.66
F-49 het 113 R-V 0.0599 0.0217 9.4 26.87 13.08 0.91
F-49 het 113 R-FL 0.0731 0.0282 9.4 26.87 27.67 0.66
F-49 het 113 R-FR 0.0678 0.0261 9.4 26.87 21.45 0.52
F-50 het 108 T-Animal Total 0.0494 0.4764 9.4 22.92 14.85 21.68
F-50 het 108 R-V 0.0597 0.0244 9.4 22.92 5.93 1.06
F-50 het 108 R-FR 0.0694 0.0289 9.4 22.92 16.69 0.51
F-50 het 108 R-FL 0.0731 0.0319 9.4 22.92 18.51 0.64
M-83 het 108 T-Animal Total 0.0487 0.4432 9.4 26.48 14.93 25.48
M-83 het 108 R-FR 0.0695 0.0282 9.4 26.48 17.96 0.59
M-83 het 108 R-FL 0.0717 0.0292 9.4 26.48 21.58 0.7
M-83 het 108 R-V 0.0513 0.0197 9.4 26.48 8.15 1.05
M-108 het 107 T-Animal Total 0.0559 0.5639 9.5 31.52 15.74 30.55
M-108 het 107 R-V 0.0606 0.0308 9.5 31.52 5.56 1.51
M-108 het 107 R-FR 0.0819 0.0407 9.5 31.52 21.7 1.04
M-108 het 107 R-FL 0.0825 0.0382 9.5 31.52 19.91 1.09
F-51 hom 108 T-Animal Total 0.0547 0.5187 9.5 26.56 18.98 25.59
F-51 hom 108 R-FR 0.0723 0.0312 9.5 26.56 20.57 0.65
F-51 hom 108 R-FL 0.0801 0.0314 9.5 26.56 23.96 0.62
F-51 hom 108 R-V 0.0651 0.0218 9.5 26.56 7.83 0.82
F-52 hom 108 T-Animal Total 0.053 0.574 9.0 25.78 14.58 24.33
F-52 hom 108 R-V 0.0656 0.0289 9.0 25.78 4.69 1.04
F-52 hom 108 R-FR 0.0739 0.0295 9.0 25.78 16.23 0.57
F-52 hom 108 R-FL 0.0792 0.0316 9.0 25.78 23.15 0.67
F-53 hom 108 T-Animal Total 0.0576 0.5735 9.5 27.76 20.51 26.63
F-53 hom 108 R-FR 0.0805 0.0333 9.5 27.76 16.1 0.52
F-53 hom 108 R-FL 0.0921 0.0376 9.5 27.76 21.36 0.65
F-53 hom 108 R-V 0.0803 0.0276 9.5 27.76 12.28 0.89
M-54 hom 108 T-Animal Total 0.062 0.6802 9.9 37.98 15.19 37.17
M-54 hom 108 R-V 0.0755 0.0331 9.9 37.98 8.31 1.5
M-54 hom 108 R-FL 0.0987 0.0453 9.9 37.98 18.9 0.89
M-54 hom 108 R-FR 0.0931 0.0457 9.9 37.98 14.63 0.78
F-63 hom 108 T-Animal Total 0.0513 0.4926 9.1 26.19 16.01 24.93
F-63 hom 108 R-FR 0.0702 0.0278 9.1 26.19 17.72 0.56
F-63 hom 108 R-V 0.0659 0.0307 9.1 26.19 5.18 1.2
F-63 hom 108 R-FL 0.0751 0.0282 9.1 26.19 23.02 0.66
F-71 hom 108 T-Animal Total 0.0513 0.4916 9.1 22.58 14.55 21.51
F-71 hom 108 R-V 0.0559 0.0233 9.1 22.58 2.45 0.91
F-71 hom 108 R-FL 0.077 0.0309 9.1 22.58 17.81 0.6
F-71 hom 108 R-FR 0.0725 0.0291 9.1 22.58 17.83 0.55
F-99 hom 108 T-Animal Total 0.0562 0.5504 9.2 24.88 17.1 23.6
F-99 hom 108 R-FR 0.0767 0.0317 9.2 24.88 17.01 0.6
F-99 hom 108 R-FL 0.0776 0.0361 9.2 24.88 20.52 0.68
F-99 hom 108 R-V 0.0718 0.0252 9.2 24.88 6.2 0.94
M-107 hom 107 T-Animal Total 0.0549 0.5962 9.7 31.48 11.93 29.94
M-107 hom 107 R-V 0.0638 0.0283 9.7 31.48 4.15 1.27
M-107 hom 107 R-FR 0.084 0.0408 9.7 31.48 12.49 0.83
M-107 hom 107 R-FL 0.0909 0.0407 9.7 31.48 15.63 0.84
M-110 hom 107 T-Animal Total 0.052 0.5039 9.5 30.04 14.46 29.13
M-110 hom 107 R-FR 0.0729 0.0304 9.5 30.04 13.88 0.74
M-110 hom 107 R-FL 0.0769 0.0329 9.5 30.04 14.87 0.78
M-110 hom 107 R-V 0.053 0.0226 9.5 30.04 8.49 1.32
M-55 wt 108 T-Animal Total 0.0609 0.6213 9.6 35.72 18.45 34.98
M-55 wt 108 R-V 0.0689 0.031 9.6 35.72 10.33 1.31
M-55 wt 108 R-FR 0.0928 0.0453 9.6 35.72 17.86 0.87
M-55 wt 108 R-FL 0.0918 0.0452 9.6 35.72 23.2 1.01
F-77 wt 108 R-V 0.0568 0.0218 9.0 22.8 12.33 1.02
F-77 wt 108 T-Animal Total 0.0463 0.375 9.0 22.8 21.62 22.0
F-77 wt 108 R-FL 0.0706 0.0247 9.0 22.8 27.09 0.6
F-77 wt 108 R-FR 0.0644 0.0234 9.0 22.8 21.08 0.5
F-88 wt 108 T-Animal Total 0.0496 0.498 9.3 24.17 19.93 22.73
F-88 wt 108 R-V 0.0561 0.0196 9.3 24.17 6.07 0.87
F-88 wt 108 R-FL 0.073 0.027 9.3 24.17 25.44 0.61
F-88 wt 108 R-FR 0.0661 0.0266 9.3 24.17 18.42 0.54
M-109 wt 107 T-Animal Total 0.0505 0.5406 9.1 27.65 9.15 26.44
M-109 wt 107 R-V 0.0635 0.0291 9.1 27.65 3.11 1.28
M-109 wt 107 R-FL 0.0806 0.0316 9.1 27.65 12.83 0.68
M-109 wt 107 R-FR 0.0751 0.0312 9.1 27.65 15.9 0.73
 


Copyright 2005 by Lexicon Genetics Incorporated
Lexicon Phenotypic Analysis software version 05.05.00.05