Inverted Screen for Project: NIH-0617 Test Description: A motor strength deficit is apparent when there is a 50% point difference between (-/-) or (+/-) mice and (+/+) mice for the fell down response. 0/8 or 1/8 (-/-) or (+/-) mice not climbing indicates impaired motor coordination. 7/8 or 8/8(-/-) or (+/-) mice climbing up indicates enhanced motor coordination.

Results Genotype Ratio Fell Down % Ratio Climbed Up % +/+ (n=4) 0/4 0 1/4 25 +/- (n=6) 2/6 34 2/6 34 -/- (n=7) 0/7 0 5/7 72 WT Population Fell Down 3.62 Climbed Up 60.04 *Red color coding indicates a notable difference.

Inverted Screen data for Project: NIH-0617 - Results        Mouse Label Genotype Age (days) Test Result Weight at Testing Comments M-38 het 98 Climbed Up 28.0 M-45 het 98 Did Not Climb 29.7 M-46 het 98 Fell Down 33.5 F-48 het 98 Climbed Up 28.6 F-50 het 98 Fell Down 26.6 M-55 het 98 Did Not Climb 24.2 F-49 hom 98 Climbed Up 18.5 F-84 hom 88 Climbed Up 23.9 F-88 hom 87 Climbed Up 21.6 F-91 hom 87 Climbed Up 24.4 M-94 hom 89 Did Not Climb 27.5 M-95 hom 89 Did Not Climb 27.0 F-99 hom 89 Climbed Up 22.3 Individually housed. M-39 wt 98 Did Not Climb 30.3 F-51 wt 98 Climbed Up 23.3 F-82 wt 88 Did Not Climb 20.9 M-96 wt 89 Did Not Climb 28.3

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Lexicon Phenotypic Analysis software version 05.05.00.05