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DEXA for Project: NIH-0617
Test Description: Mice were anesthetized by intraperitoneal injection of Avertin (1.25% 2,2,2,-tribromoethanol, 20 ml/kg body weight ), measured body length and weight, and then placed in a prone position on the platform of the PIXImusTM Densitometer (Lunar Inc.) for a DEXA scan. Using a Lunar PIXImus software, the Bone mineral density (BMD) and fat composition (% fat) and total tissue mass (TTM) were determined in the regions of interest (ROI, i.e., whole body, vertebrae, and both femurs).


Results

  BMD = Bone Mineral Density (g/cm2);
  BMC = Bone Mineral Content (g);
  LBM = Lean Body Mass (g);
  BMC / LBM = BMC / LBM (mg/g); 		  FAT(%) = % of Body FAT;
  FAT(g) = TTM X FAT(%)/100;
  TTM = Total Tissue Mass (g);
  vBMD = Volumetric BMD (mg/cm3)

MALE DATA




FEMALE DATA



DEXA Combined Gender Score
Parameter Score
Body BMD  96.6%
Body vBMD  97.1%
Body BMC/LBM  96.3%
Femur BMD  97.4%
Vertebral BMD  97.1%
Total Tissue Mass  95.2%
Body LBM  98.9%
Body % Fat  86.3%
Body Fat Content  82.3%
The Combined Gender Score provides the average ration of Hom to WT values combining
males and females, with a correction factor for the number of mice in each group. No score
is generated if there are fewer than 4 HOM mice or fewer than 3 WT mice


DEXA Analysis: Male
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
M-39wt0.05090.535828.8617.0623.422.915.680.06480.08790000
M-96wt0.0520.482926.5322.3920.1124.0217.060.06650.08650000
M-38het0.04760.466426.4516.1921.721.4915.20.05250.07885000
M-45het0.04770.438528.0120.7621.7620.1515.730.05270.07300000
M-46het0.05120.517132.3818.6625.8220.0316.120.05110.08380000
M-55het0.04860.455522.2315.7318.2824.9215.870.05950.07060000
M-94hom0.04920.442228.2224.4520.8821.1816.410.06490.07895000
M-95hom0.04490.450525.0814.021.1221.3314.170.05360.07310000

DEXA Analysis: Female
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
F-51wt0.05030.444524.9826.1218.0124.6816.920.06950.07180000
F-82wt0.04790.471119.8716.8616.0529.3515.270.070.07250000
F-48het0.05720.632129.1619.4122.8727.6417.20.07490.08700000
F-50het0.05030.486626.4423.1619.8324.5416.170.07110.07660000
F-49hom0.0480.436819.615.5716.1127.1115.910.06260.06915000
F-84hom0.05170.51524.321.5418.5527.7616.380.0710.08715000
F-88hom0.05050.450721.2215.9717.3825.9316.910.06430.07740000
F-91hom0.04620.446319.7915.4816.2827.4114.860.05420.06730000
F-99hom0.04810.448121.1117.2917.0126.3415.760.06160.07120000




  DEXA Analysis data        Export Data to Spreadsheet
Mouse
Label 		Genotype Age (days) Site BMD BMC Length Weight FAT TTM
M-38 het 110 T-Animal Total 0.0476 0.4664 9.7 28.03 16.19 26.45
M-38 het 110 R-FR 0.0774 0.0317 9.7 28.03 14.33 0.65
M-38 het 110 R-FL 0.0803 0.0289 9.7 28.03 19.36 0.67
M-38 het 110 R-V 0.0525 0.0224 9.7 28.03 7.07 0.9
M-45 het 110 T-Animal Total 0.0477 0.4385 10.0 29.77 20.76 28.01
M-45 het 110 R-FR 0.0712 0.0272 10.0 29.77 21.98 0.65
M-45 het 110 R-V 0.0527 0.0221 10.0 29.77 9.9 0.88
M-45 het 110 R-FL 0.0748 0.0263 10.0 29.77 28.0 0.63
M-46 het 110 R-FR 0.0787 0.0357 10.2 33.99 17.04 0.94
M-46 het 110 T-Animal Total 0.0512 0.5171 10.2 33.99 18.66 32.38
M-46 het 110 R-V 0.0511 0.0198 10.2 33.99 9.38 0.95
M-46 het 110 R-FL 0.0889 0.0363 10.2 33.99 26.68 0.81
F-48 het 110 T-Animal Total 0.0572 0.6321 10.2 30.9 19.41 29.16
F-48 het 110 R-FL 0.087 0.0428 10.2 30.9 28.46 0.87
F-48 het 110 R-FR 0.087 0.0422 10.2 30.9 21.58 0.76
F-48 het 110 R-V 0.0749 0.0338 10.2 30.9 10.53 0.84
F-50 het 110 T-Animal Total 0.0503 0.4866 10.0 28.02 23.16 26.44
F-50 het 110 R-FL 0.0778 0.0294 10.0 28.02 32.39 0.66
F-50 het 110 R-FR 0.0754 0.0307 10.0 28.02 26.0 0.61
F-50 het 110 R-V 0.0711 0.0281 10.0 28.02 15.21 0.76
M-55 het 110 T-Animal Total 0.0486 0.4555 9.5 24.08 15.73 22.23
M-55 het 110 R-V 0.0595 0.0262 9.5 24.08 6.82 0.76
M-55 het 110 R-FL 0.0735 0.0254 9.5 24.08 19.59 0.63
M-55 het 110 R-FR 0.0677 0.0242 9.5 24.08 18.25 0.54
F-49 hom 110 T-Animal Total 0.048 0.4368 9.0 20.76 15.57 19.6
F-49 hom 110 R-V 0.0626 0.0273 9.0 20.76 5.5 0.79
F-49 hom 110 R-FL 0.0695 0.024 9.0 20.76 22.49 0.54
F-49 hom 110 R-FR 0.0688 0.0249 9.0 20.76 24.91 0.53
F-84 hom 108 T-Animal Total 0.0517 0.515 9.4 26.0 21.54 24.3
F-84 hom 108 R-V 0.071 0.0289 9.4 26.0 10.57 0.69
F-84 hom 108 R-FR 0.0841 0.0322 9.4 26.0 19.27 0.48
F-84 hom 108 R-FL 0.0902 0.0305 9.4 26.0 22.9 0.51
F-88 hom 107 T-Animal Total 0.0505 0.4507 9.1 22.75 15.97 21.22
F-88 hom 107 R-FR 0.0732 0.024 9.1 22.75 16.33 0.39
F-88 hom 107 R-FL 0.0816 0.0232 9.1 22.75 20.91 0.39
F-88 hom 107 R-V 0.0643 0.0266 9.1 22.75 8.05 0.68
F-91 hom 107 T-Animal Total 0.0462 0.4463 9.5 21.18 15.48 19.79
F-91 hom 107 R-V 0.0542 0.0226 9.5 21.18 5.61 0.61
F-91 hom 107 R-FR 0.0664 0.026 9.5 21.18 15.5 0.47
F-91 hom 107 R-FL 0.0682 0.0237 9.5 21.18 18.56 0.48
M-94 hom 101 T-Animal Total 0.0492 0.4422 9.6 29.69 24.45 28.22
M-94 hom 101 R-V 0.0649 0.0267 9.6 29.69 10.59 0.77
M-94 hom 101 R-FR 0.0722 0.0251 9.6 29.69 29.43 0.54
M-94 hom 101 R-FL 0.0857 0.0252 9.6 29.69 27.97 0.44
M-95 hom 101 T-Animal Total 0.0449 0.4505 9.8 26.64 14.0 25.08
M-95 hom 101 R-V 0.0536 0.0213 9.8 26.64 5.85 0.71
M-95 hom 101 R-FR 0.0701 0.0274 9.8 26.64 7.57 0.5
M-95 hom 101 R-FL 0.0761 0.0267 9.8 26.64 13.84 0.49
F-99 hom 101 T-Animal Total 0.0481 0.4481 9.4 22.73 17.29 21.11
F-99 hom 101 R-V 0.0616 0.0255 9.4 22.73 6.16 0.65
F-99 hom 101 R-FR 0.0706 0.0249 9.4 22.73 18.23 0.38
F-99 hom 101 R-FL 0.0718 0.0247 9.4 22.73 22.23 0.51
M-39 wt 110 T-Animal Total 0.0509 0.5358 10.1 30.41 17.06 28.86
M-39 wt 110 R-V 0.0648 0.0289 10.1 30.41 9.43 0.88
M-39 wt 110 R-FL 0.0943 0.0389 10.1 30.41 20.0 0.71
M-39 wt 110 R-FR 0.0815 0.0363 10.1 30.41 19.01 0.69
F-51 wt 110 T-Animal Total 0.0503 0.4445 9.7 26.22 26.12 24.98
F-51 wt 110 R-FR 0.07 0.0258 9.7 26.22 28.32 0.56
F-51 wt 110 R-V 0.0695 0.0311 9.7 26.22 14.56 0.85
F-51 wt 110 R-FL 0.0736 0.0286 9.7 26.22 31.69 0.71
F-82 wt 108 T-Animal Total 0.0479 0.4711 9.3 21.39 16.86 19.87
F-82 wt 108 R-V 0.07 0.0298 9.3 21.39 11.19 0.6
F-82 wt 108 R-FR 0.072 0.0241 9.3 21.39 17.5 0.37
F-82 wt 108 R-FL 0.073 0.0252 9.3 21.39 20.45 0.48
M-96 wt 101 T-Animal Total 0.052 0.4829 9.7 27.97 22.39 26.53
M-96 wt 101 R-V 0.0665 0.0264 9.7 27.97 12.38 0.73
M-96 wt 101 R-FR 0.0815 0.0309 9.7 27.97 18.8 0.54
M-96 wt 101 R-FL 0.0915 0.0281 9.7 27.97 22.78 0.5
 


Copyright 2005 by Lexicon Genetics Incorporated
Lexicon Phenotypic Analysis software version 05.05.00.05