Stress Induced Hyperthermia for Project: NIH-1841 Test Description: (SIH) is a measurement of autonomic hyperactivity induced by anxiety-provoking stimuli. The method involves taking two rectal body temperature measurements 10 minutes apart. SIH is determined by subtracting the basal body temperature (T1) from the stress-enhanced temperature (T2). The difference in delta values (T2 - T1 = deltaT) indicates the severity of autonomic hyperactivity or SIH. The rise in body temperature associated with SIH is a sign of anticipatory anxiety to the second rectal body temperature measurement. Lower deltaT values suggest decreased anxiety-like responses. Assay-Specific Summary :NIH-1841 Results Stress-Induced Hyperthermia: No notable difference.

Results

Stress-Induced Hyperthermia Analysis data Mouse Label Genotype Age (days) Stress Temperature Basal Temperature M-104 het 67 38.0 35.2 M-107 het 67 37.9 35.8 M-115 het 66 37.9 36.6 M-124 het 66 38.1 36.9 M-79 wt 69 37.8 35.7 M-108 wt 67 37.5 36.1

Confidential Information

Copyright 2006 by Lexicon Genetics Incorporated