Inverted Screen for Project: NIH-1841 Test Description: A motor strength deficit is apparent when there is a 50% point difference between (-/-) or (+/-) mice and (+/+) mice for the fell down response. 0/8 or 1/8 (-/-) or (+/-) mice not climbing indicates impaired motor coordination. 7/8 or 8/8(-/-) or (+/-) mice climbing up indicates enhanced motor coordination. Assay-Specific Summary :NIH-1841 Results Inverted Screen: No notable difference.

Results Genotype Ratio Fell Down % Ratio Climbed Up % +/+ (n=4) 0/4 0 2/4 50 +/- (n=8) 1/8 13 3/8 38 WT Population Fell Down 3.62 Climbed Up 60.04 *Red color coding indicates a notable difference.

Inverted Screen data for Project: NIH-1841 - Results Mouse Label Genotype Age (days) Test Result Weight at Testing Comments F-83 het 84 Did Not Climb 25.6 F-91 het 84 Did Not Climb 19.8 F-95 het 83 Climbed Up 24.9 22 seconds M-104 het 82 Fell Down 32.6 42 seconds M-107 het 82 Did Not Climb 31.6 M-115 het 81 Did Not Climb 25.3 M-124 het 81 Climbed Up 25.3 32 seconds F-130 het 80 Climbed Up 22.1 18 seconds M-79 wt 84 Did Not Climb 31.3 F-102 wt 83 Climbed Up 22.8 55 seconds M-108 wt 82 Did Not Climb 29.1 F-121 wt 81 Climbed Up 24.3 11 seconds

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