Gene Summary for NIH-0516
Functional Category: signal transduction-receptor-gpcr
Cell Location: integral membrane
OST #:
Mouse Nucleotide Accession #: AK021164
Human Nucleotide Accession #: NM_003508

The gene of interest is mouse Fzd9 (frizzled homolog 9 [Drosophila]), ortholog of human FZD9. Aliases include mfz9 and FZD3.

Phenotypic Summary for NIH-0516
The male homozygous mutant mice exhibited signs of growth retardation, including decreased mean body weight and length, total tissue mass, lean body mass, and bone mineral-related measurements. Disruption of the target gene was confirmed by Southern hybridization analysis.

Mouse Gene Sequence Information
Nucleotide Reference: AK021164 ACCESSION:AK021164 NID:12861957 Mus musculus Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130077B15 product:frizzled homolog 9 (Drosophila), full insert sequence. gbhtc
Protein Reference: Q9R216 ACCESSION:Q9R216 NID: Mus musculus (Mouse). Frizzled 9 precursor (Frizzled-9) (Fz-9) (mFz9) (mFz3). MOUSESPTRNRDB
Entrez Gene: 14371

Human Gene Sequence Information
Nucleotide Reference: NM_003508 ACCESSION:NM_003508 NID: gi 4503834 ref NM_003508.1 Homo sapiens frizzled homolog 9 (Drosophila) (FZD9), mRNA
Protein Reference: O00144 ACCESSION:O00144 NID: Homo sapiens (Human). Frizzled 9 precursor (Frizzled-9) (Fz-9) (hFz9) (FzE6). HUMANSPTRNRDB
Entrez Gene: 8326

Mutation Information
Mutation Type: Homologous Recombination (standard)
Description: The single exon (NCBI accession AK021164) was targeted.

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