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Acute Phase Response for Project: NIH-0516
Test Description: Bacterial lipopolysaccharide (LPS) is an endotoxin, a potent inducer of the acute phase response and systemic inflammation. The mice will:
  • Be injected intraperitoneally (i.p.) with a sublethal dose of LPS in 200 µL sterile saline using a 26 gauge needle.
  • The dose will be based on the average weight of the mice tested at 1 µg/g body weight 3 hours after injection, a 100ul blood sample will be taken and analyzed for the presence of TNFα, MCP-1, and IL-6 on the FACSCalibur.


Results





  Acute Phase Response data for Project: NIH-0516 - Results        Export Data to Spreadsheet
Mouse Label Genotype Age (days) TNF-a MCP-1 IL-6
M-95 hom 123 1000.9 53305.9 32162.7
M-104 hom 123 966.5 52337.4 35126.8
M-114 hom 123 2425.3 76969.5 58125.1
M-116 hom 123 1110.5 36167.3 27330.9
M-76 wt 125 1504.9 43239.5 26208.0
M-102 wt 123 828.9 49262.8 29036.3
M-131 wt 122 1182.4 58869.0 41306.5
M-143 wt 122 586.9 31151.9 7818.7
 


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Lexicon Phenotypic Analysis software version 05.05.00.05