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DEXA for Project: NIH-0516
Test Description: Mice were anesthetized by intraperitoneal injection of Avertin (1.25% 2,2,2,-tribromoethanol, 20 ml/kg body weight ), measured body length and weight, and then placed in a prone position on the platform of the PIXImusTM Densitometer (Lunar Inc.) for a DEXA scan. Using a Lunar PIXImus software, the Bone mineral density (BMD) and fat composition (% fat) and total tissue mass (TTM) were determined in the regions of interest (ROI, i.e., whole body, vertebrae, and both femurs).


Results

  BMD = Bone Mineral Density (g/cm2);
  BMC = Bone Mineral Content (g);
  LBM = Lean Body Mass (g);
  BMC / LBM = BMC / LBM (mg/g); 		  FAT(%) = % of Body FAT;
  FAT(g) = TTM X FAT(%)/100;
  TTM = Total Tissue Mass (g);
  vBMD = Volumetric BMD (mg/cm3)

MALE DATA




FEMALE DATA



DEXA Combined Gender Score
Parameter Score
Body BMD  97.5%
Body vBMD  99.1%
Body BMC/LBM  102.9%
Femur BMD  93.3%
Vertebral BMD  99.1%
Total Tissue Mass  91.7%
Body LBM  91.9%
Body % Fat  98.3%
Body Fat Content  92.8%
The Combined Gender Score provides the average ration of Hom to WT values combining
males and females, with a correction factor for the number of mice in each group. No score
is generated if there are fewer than 4 HOM mice or fewer than 3 WT mice


DEXA Analysis: Male
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
M-143wt0.05260.489830.2226.3321.7722.517.250.06480.07990000
M-76wt0.05490.568332.4620.5225.2322.5217.060.0630.08575000
M-75het0.05490.550229.5719.9523.1223.817.330.07380.08570000
M-85het0.05240.546130.421.3423.3723.3716.230.06540.07930000
M-104hom0.05020.451526.8522.8520.2622.2816.740.06920.07470000
M-114hom0.04620.411623.4718.8418.6422.0915.480.05010.06855001
M-116hom0.05570.566326.3413.9222.1125.6217.470.06930.07935000
M-95hom0.04550.424724.6821.2819.022.3514.90.04590.06275000

DEXA Analysis: Female
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
F-107wt0.04830.440821.8219.017.2325.5815.990.05370.06920000
F-142wt0.04930.479122.9318.6418.1826.3615.810.06640.07179999
F-119het0.05060.473222.3122.4116.8428.116.540.060.07470000
F-89het0.05070.499524.9624.6518.3127.2816.150.06370.07105000
F-101hom0.05150.462518.9416.8415.2930.2517.20.06360.07230000
F-108hom0.04960.454524.6626.417.725.6816.380.05590.06980000
F-135hom0.04860.43321.3921.4316.3726.4516.280.06060.06700000
F-78hom0.05150.510426.7221.520.4624.9416.360.06640.07435000




  DEXA Analysis data        Export Data to Spreadsheet
Mouse
Label 		Genotype Age (days) Site BMD BMC Length Weight FAT TTM
M-75 het 113 T-Animal Total 0.0549 0.5502 9.8 31.05 19.95 29.57
M-75 het 113 R-V 0.0738 0.0346 9.8 31.05 10.55 1.04
M-75 het 113 R-FL 0.091 0.0434 9.8 31.05 22.65 1.03
M-75 het 113 R-FR 0.0804 0.0403 9.8 31.05 15.46 0.98
M-85 het 113 R-V 0.0654 0.0318 9.7 31.37 9.84 1.04
M-85 het 113 R-FL 0.0795 0.0394 9.7 31.37 19.5 1.1
M-85 het 113 R-FR 0.0791 0.0404 9.7 31.37 22.46 1.04
M-85 het 113 T-Animal Total 0.0524 0.5461 9.7 31.37 21.34 30.4
F-89 het 113 T-Animal Total 0.0507 0.4995 9.6 26.19 24.65 24.96
F-89 het 113 R-FL 0.0722 0.032 9.6 26.19 31.9 1.0
F-89 het 113 R-V 0.0637 0.0257 9.6 26.19 14.87 0.85
F-89 het 113 R-FR 0.0699 0.0334 9.6 26.19 22.17 0.94
F-119 het 111 T-Animal Total 0.0506 0.4732 9.5 23.2 22.41 22.31
F-119 het 111 R-V 0.06 0.0234 9.5 23.2 12.45 0.68
F-119 het 111 R-FR 0.0729 0.033 9.5 23.2 22.79 0.77
F-119 het 111 R-FL 0.0765 0.0314 9.5 23.2 30.41 0.8
F-78 hom 113 T-Animal Total 0.0515 0.5104 9.5 27.07 21.5 26.72
F-78 hom 113 R-V 0.0664 0.0274 9.5 27.07 10.19 0.88
F-78 hom 113 R-FR 0.0725 0.0353 9.5 27.07 25.2 0.9
F-78 hom 113 R-FL 0.0762 0.0351 9.5 27.07 26.65 0.86
M-95 hom 111 T-Animal Total 0.0455 0.4247 9.3 25.36 21.28 24.68
M-95 hom 111 R-FL 0.063 0.028 9.3 25.36 24.86 0.92
M-95 hom 111 R-V 0.0459 0.0189 9.3 25.36 11.08 0.86
M-95 hom 111 R-FR 0.0625 0.0272 9.3 25.36 21.3 0.86
F-101 hom 111 T-Animal Total 0.0515 0.4625 8.5 20.39 16.84 18.94
F-101 hom 111 R-V 0.0636 0.0241 8.5 20.39 9.14 0.84
F-101 hom 111 R-FR 0.0714 0.0298 8.5 20.39 16.02 0.61
F-101 hom 111 R-FL 0.0732 0.0308 8.5 20.39 22.27 0.75
M-104 hom 111 T-Animal Total 0.0502 0.4515 9.5 27.64 22.85 26.85
M-104 hom 111 R-V 0.0692 0.0313 9.5 27.64 10.77 0.84
M-104 hom 111 R-FL 0.0763 0.0308 9.5 27.64 23.4 0.91
M-104 hom 111 R-FR 0.0731 0.0302 9.5 27.64 20.02 0.86
F-108 hom 111 T-Animal Total 0.0496 0.4545 9.5 25.51 26.4 24.66
F-108 hom 111 R-FR 0.0694 0.0322 9.5 25.51 27.14 0.88
F-108 hom 111 R-FL 0.0702 0.0285 9.5 25.51 30.8 0.89
F-108 hom 111 R-V 0.0559 0.0216 9.5 25.51 15.16 0.84
M-114 hom 111 T-Animal Total 0.0462 0.4116 8.7 24.76 18.84 23.47
M-114 hom 111 R-V 0.0501 0.019 8.7 24.76 6.98 0.78
M-114 hom 111 R-FL 0.0705 0.0265 8.7 24.76 23.06 0.82
M-114 hom 111 R-FR 0.0666 0.0263 8.7 24.76 15.7 0.73
M-116 hom 111 T-Animal Total 0.0557 0.5663 9.7 28.21 13.92 26.34
M-116 hom 111 R-FL 0.0802 0.0385 9.7 28.21 16.85 0.92
M-116 hom 111 R-FR 0.0785 0.0381 9.7 28.21 13.45 0.88
M-116 hom 111 R-V 0.0693 0.0308 9.7 28.21 5.26 0.95
F-135 hom 110 T-Animal Total 0.0486 0.433 9.0 22.61 21.43 21.39
F-135 hom 110 R-V 0.0606 0.0248 9.0 22.61 10.63 0.9
F-135 hom 110 R-FR 0.0676 0.0312 9.0 22.61 24.14 0.88
F-135 hom 110 R-FL 0.0664 0.0294 9.0 22.61 26.34 0.88
M-76 wt 113 T-Animal Total 0.0549 0.5683 10.2 34.12 20.52 32.46
M-76 wt 113 R-V 0.063 0.0271 10.2 34.12 11.78 1.12
M-76 wt 113 R-FR 0.0826 0.0453 10.2 34.12 20.1 1.1
M-76 wt 113 R-FL 0.0889 0.0598 10.2 34.12 18.41 1.47
F-107 wt 111 T-Animal Total 0.0483 0.4408 8.8 23.67 19.0 21.82
F-107 wt 111 R-V 0.0537 0.0218 8.8 23.67 7.95 0.76
F-107 wt 111 R-FL 0.0693 0.029 8.8 23.67 23.55 0.84
F-107 wt 111 R-FR 0.0691 0.0302 8.8 23.67 19.73 0.73
F-142 wt 110 T-Animal Total 0.0493 0.4791 9.7 24.41 18.64 22.93
F-142 wt 110 R-V 0.0664 0.0266 9.7 24.41 8.46 0.85
F-142 wt 110 R-FL 0.0747 0.0297 9.7 24.41 25.12 0.8
F-142 wt 110 R-FR 0.0689 0.0314 9.7 24.41 20.49 0.84
M-143 wt 110 T-Animal Total 0.0526 0.4898 10.1 30.59 26.33 30.22
M-143 wt 110 R-V 0.0648 0.0274 10.1 30.59 13.89 1.1
M-143 wt 110 R-FL 0.0814 0.0413 10.1 30.59 28.05 1.22
M-143 wt 110 R-FR 0.0784 0.0394 10.1 30.59 26.21 1.14
 


Copyright 2005 by Lexicon Genetics Incorporated
Lexicon Phenotypic Analysis software version 05.05.00.05