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Acute Phase Response for Project: NIH-1790
Test Description: Bacterial lipopolysaccharide (LPS) is an endotoxin, a potent inducer of the acute phase response and systemic inflammation. The mice will:
  • Be injected intraperitoneally (i.p.) with a sublethal dose of LPS in 200 µL sterile saline using a 26 gauge needle.
  • The dose will be based on the average weight of the mice tested at 1 µg/g body weight 3 hours after injection, a 100ul blood sample will be taken and analyzed for the presence of TNFα, MCP-1, and IL-6 on the FACSCalibur.


Results





  Acute Phase Response data for Project: NIH-1790 - Results        Export Data to Spreadsheet
Mouse Label Genotype Age (days) TNF-a MCP-1 IL-6
M-122 hom 109 867.6 45100.0 6055.0
M-127 hom 108 899.1 37775.7 6145.0
M-130 hom 108 617.6 37775.7 4745.7
M-135 hom 108 607.7 37775.7 5512.3
M-123 wt 109 647.7 36475.6 4841.9
M-143 wt 108 1454.4 71240.9 14402.7
M-150 wt 108 812.9 41745.5 6979.2
M-153 wt 108 1033.5 60195.3 9967.9
 


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