Inverted Screen for Project: NIH-1790 Test Description: A motor strength deficit is apparent when there is a 50% point difference between (-/-) or (+/-) mice and (+/+) mice for the fell down response. 0/8 or 1/8 (-/-) or (+/-) mice not climbing indicates impaired motor coordination. 7/8 or 8/8(-/-) or (+/-) mice climbing up indicates enhanced motor coordination.

Results Genotype Ratio Fell Down % Ratio Climbed Up % +/+ (n=4) 0/4 0 1/4 25 +/- (n=4) 1/4 25 2/4 50 -/- (n=8) 0/8 0 2/8 25 WT Population Fell Down 3.62 Climbed Up 60.04 *Red color coding indicates a notable difference.

Inverted Screen data for Project: NIH-1790 - Results        Mouse Label Genotype Age (days) Test Result Weight at Testing Comments F-103 het 78 Did Not Climb 22.1 F-117 het 74 Climbed Up 25.4 3 seconds M-121 het 74 Fell Down 32.6 15 seconds M-129 het 73 Climbed Up 32.5 53 seconds F-104 hom 78 Did Not Climb 22.5 F-105 hom 78 Climbed Up 20.1 12 seconds F-111 hom 78 Did Not Climb 22.6 F-115 hom 74 Climbed Up 22.2 11 seconds M-122 hom 74 Did Not Climb 29.1 M-127 hom 73 Did Not Climb 30.7 M-130 hom 73 Did Not Climb 30.7 M-135 hom 73 Did Not Climb 28.7 F-110 wt 78 Did Not Climb 22.1 F-132 wt 73 Climbed Up 24.4 22 seconds M-143 wt 73 Did Not Climb 24.4 M-150 wt 73 Did Not Climb 28.8

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Lexicon Phenotypic Analysis software version 05.05.00.05