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DEXA for Project: NIH-1790
Test Description: Mice were anesthetized by intraperitoneal injection of Avertin (1.25% 2,2,2,-tribromoethanol, 20 ml/kg body weight ), measured body length and weight, and then placed in a prone position on the platform of the PIXImusTM Densitometer (Lunar Inc.) for a DEXA scan. Using a Lunar PIXImus software, the Bone mineral density (BMD) and fat composition (% fat) and total tissue mass (TTM) were determined in the regions of interest (ROI, i.e., whole body, vertebrae, and both femurs).


Results

  BMD = Bone Mineral Density (g/cm2);
  BMC = Bone Mineral Content (g);
  LBM = Lean Body Mass (g);
  BMC / LBM = BMC / LBM (mg/g); 		  FAT(%) = % of Body FAT;
  FAT(g) = TTM X FAT(%)/100;
  TTM = Total Tissue Mass (g);
  vBMD = Volumetric BMD (mg/cm3)

MALE DATA




FEMALE DATA



DEXA Combined Gender Score
Parameter Score
Body BMD  100.9%
Body vBMD  99.4%
Body BMC/LBM  101.5%
Femur BMD  95.6%
Vertebral BMD  99.4%
Total Tissue Mass  101.5%
Body LBM  103.3%
Body % Fat  93.3%
Body Fat Content  96.1%
The Combined Gender Score provides the average ration of Hom to WT values combining
males and females, with a correction factor for the number of mice in each group. No score
is generated if there are fewer than 4 HOM mice or fewer than 3 WT mice


DEXA Analysis: Male
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
M-143wt0.04720.464522.9317.6418.4225.2215.050.05170.06925000
M-150wt0.05160.506528.5122.4221.6123.4416.470.06360.08110000
M-121het0.05820.61132.4722.6424.5124.9317.960.06440.09490000
M-129het0.05480.594933.3328.1423.3625.4716.630.05750.07970000
M-122hom0.04990.474129.8520.4223.2820.3616.180.05190.06580000
M-127hom0.04830.473130.1224.4222.2921.2215.430.05650.06985000
M-130hom0.04790.432429.3126.1721.2120.3915.940.04240.07485000
M-135hom0.04910.538426.5913.2422.5323.914.830.05190.07150000

DEXA Analysis: Female
Mouse Label Genotype Whole Body Vertebrae Femurs
BMD (g/cm2) BMC (g) TTM % FAT LBM (g) BMC / LBM (mg/g) vBMD (mg/cm3) BMD (g/cm2) BMD (g/cm2)
F-110wt0.04990.446422.7624.5816.7226.716.690.05580.07170000
F-132wt0.04610.415324.1721.0718.6622.2515.360.05290.06784999
F-103het0.04730.44121.4621.3316.4426.8215.490.04820.06825000
F-117het0.04550.394125.1629.5617.3322.7415.470.04960.06915000
F-104hom0.04680.443321.3917.3117.2425.7115.210.05570.06395000
F-105hom0.04470.408920.0220.4315.5226.3414.790.05230.05885000
F-111hom0.05120.476922.2321.6516.9428.1516.770.06270.07395000
F-115hom0.05510.562321.2715.0317.5132.1117.250.06620.07529999




  DEXA Analysis data        Export Data to Spreadsheet
Mouse
Label 		Genotype Age (days) Site BMD BMC Length Weight FAT TTM
F-103 het 101 T-Animal Total 0.0473 0.441 9.2 22.88 21.33 21.46
F-103 het 101 R-V 0.0482 0.0208 9.2 22.88 8.28 1.03
F-103 het 101 R-FL 0.0709 0.0275 9.2 22.88 28.35 0.64
F-103 het 101 R-FR 0.0656 0.0268 9.2 22.88 17.78 0.54
F-117 het 97 T-Animal Total 0.0455 0.3941 9.7 26.26 29.56 25.16
F-117 het 97 R-FR 0.0662 0.0266 9.7 26.26 27.59 0.64
F-117 het 97 R-V 0.0496 0.0139 9.7 26.26 16.14 0.76
F-117 het 97 R-FL 0.0721 0.0265 9.7 26.26 35.17 0.73
M-121 het 97 T-Animal Total 0.0582 0.611 10.3 34.35 22.64 32.47
M-121 het 97 R-V 0.0644 0.0232 10.3 34.35 10.45 1.02
M-121 het 97 R-FL 0.0989 0.0421 10.3 34.35 23.58 0.73
M-121 het 97 R-FR 0.0909 0.0385 10.3 34.35 16.48 0.69
M-129 het 96 T-Animal Total 0.0548 0.5949 10.2 34.34 28.14 33.33
M-129 het 96 R-V 0.0575 0.0235 10.2 34.34 20.06 1.16
M-129 het 96 R-FR 0.0801 0.039 10.2 34.34 24.25 0.86
M-129 het 96 R-FL 0.0793 0.0413 10.2 34.34 23.56 1.03
F-104 hom 101 T-Animal Total 0.0468 0.4433 9.5 22.66 17.31 21.39
F-104 hom 101 R-V 0.0557 0.0174 9.5 22.66 5.0 0.73
F-104 hom 101 R-FR 0.0618 0.0249 9.5 22.66 14.55 0.51
F-104 hom 101 R-FL 0.0661 0.0274 9.5 22.66 23.67 0.63
F-105 hom 101 T-Animal Total 0.0447 0.4089 9.0 21.33 20.43 20.02
F-105 hom 101 R-FR 0.0569 0.0199 9.0 21.33 21.65 0.49
F-105 hom 101 R-FL 0.0608 0.0205 9.0 21.33 25.56 0.55
F-105 hom 101 R-V 0.0523 0.0202 9.0 21.33 7.7 0.83
F-111 hom 101 T-Animal Total 0.0512 0.4769 9.2 23.42 21.65 22.23
F-111 hom 101 R-FR 0.0738 0.031 9.2 23.42 20.22 0.61
F-111 hom 101 R-V 0.0627 0.0196 9.2 23.42 10.66 0.81
F-111 hom 101 R-FL 0.0741 0.0308 9.2 23.42 22.3 0.66
F-115 hom 97 T-Animal Total 0.0551 0.5623 9.2 22.95 15.03 21.27
F-115 hom 97 R-V 0.0662 0.027 9.2 22.95 5.11 0.97
F-115 hom 97 R-FL 0.0764 0.0284 9.2 22.95 22.09 0.59
F-115 hom 97 R-FR 0.0742 0.032 9.2 22.95 13.6 0.6
M-122 hom 97 T-Animal Total 0.0499 0.4741 9.7 31.12 20.42 29.85
M-122 hom 97 R-FR 0.0643 0.024 9.7 31.12 22.76 0.76
M-122 hom 97 R-V 0.0519 0.0168 9.7 31.12 12.0 1.21
M-122 hom 97 R-FL 0.0673 0.0271 9.7 31.12 19.59 0.79
M-127 hom 96 T-Animal Total 0.0483 0.4731 9.8 31.02 24.42 30.12
M-127 hom 96 R-V 0.0565 0.0262 9.8 31.02 16.0 1.25
M-127 hom 96 R-FL 0.0718 0.0257 9.8 31.02 25.29 0.69
M-127 hom 96 R-FR 0.0679 0.0276 9.8 31.02 22.11 0.64
M-130 hom 96 T-Animal Total 0.0479 0.4324 10.1 30.49 26.17 29.31
M-130 hom 96 R-V 0.0424 0.0141 10.1 30.49 15.9 0.97
M-130 hom 96 R-FR 0.0716 0.0266 10.1 30.49 20.41 0.56
M-130 hom 96 R-FL 0.0781 0.0277 10.1 30.49 27.33 0.63
M-135 hom 96 T-Animal Total 0.0491 0.5384 10.0 28.43 13.24 26.59
M-135 hom 96 R-FR 0.0698 0.0314 10.0 28.43 10.91 0.74
M-135 hom 96 R-FL 0.0732 0.03 10.0 28.43 15.68 0.8
M-135 hom 96 R-V 0.0519 0.0239 10.0 28.43 4.75 1.21
F-110 wt 101 T-Animal Total 0.0499 0.4464 9.3 24.2 24.58 22.76
F-110 wt 101 R-V 0.0558 0.02 9.3 24.2 8.7 0.9
F-110 wt 101 R-FR 0.0708 0.0267 9.3 24.2 23.43 0.58
F-110 wt 101 R-FL 0.0726 0.0259 9.3 24.2 30.53 0.62
F-132 wt 96 T-Animal Total 0.0461 0.4153 9.6 25.4 21.07 24.17
F-132 wt 96 R-FR 0.0659 0.027 9.6 25.4 20.56 0.68
F-132 wt 96 R-FL 0.0698 0.0255 9.6 25.4 28.56 0.72
F-132 wt 96 R-V 0.0529 0.0225 9.6 25.4 11.53 1.07
M-143 wt 96 T-Animal Total 0.0472 0.4645 9.4 24.4 17.64 22.93
M-143 wt 96 R-V 0.0517 0.0175 9.4 24.4 5.75 0.86
M-143 wt 96 R-FL 0.0739 0.0254 9.4 24.4 23.03 0.58
M-143 wt 96 R-FR 0.0646 0.024 9.4 24.4 14.29 0.5
M-150 wt 96 T-Animal Total 0.0516 0.5065 9.9 29.88 22.42 28.51
M-150 wt 96 R-V 0.0636 0.0327 9.9 29.88 14.12 1.4
M-150 wt 96 R-FL 0.0853 0.0329 9.9 29.88 24.82 0.73
M-150 wt 96 R-FR 0.0769 0.0333 9.9 29.88 21.61 0.78
 


Copyright 2005 by Lexicon Genetics Incorporated
Lexicon Phenotypic Analysis software version 05.05.00.05