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Ift172 Gene Detail
 Symbol
Name
ID
Ift172
intraflagellar transport 172 homolog (Chlamydomonas)
MGI:2682064


Nomenclature History
Synonyms 4930553F24Rik, wim
Genetic Map
Chromosome 5
cytoband B1
 
Mapping data( 2)
Sequence Map
Chr5:31555653-31593487 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF312901
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000038564 Ensembl Gene Model | MGI Sequence Detail 37835 C57BL/6J ± Kb
transcript NM_026298 RefSeq | MGI Sequence Detail 5440 C57BL/6
polypeptide Q6VH22 UniProt | EBI | MGI Sequence Detail 1749 Not Applicable
For the selected sequences
All sequences(26)
Alleles
and
phenotypes
All alleles(6) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(2) Chemically induced(1)
Mice homozygous for disruptions in this gene display embryonic lethality during organogenesis, neural tube defects, and developmental patterning abnormalities. Mice homozygous for a conditional allele activated in the early limb bud exhibit polydactyly and short limbs.
Polymorphisms SNPs within 2kb(118 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cilium assembly, determination of left/right symmetry...
Component cell projection, cilium...
Function protein binding
External Resources: FuncBase
Expression Literature Summary: (3 records)
cDNA source data(77)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(77) cDNA(77)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000038564
DoTS DT.110687661, DT.531784, DT.94182892, DT.97333550
Consensus CDS Project CCDS39054.1
UniGene 293023
DFCI TC1576418, TC1587450
Entrez Gene 67661
International Mouse Knockout Project Status Ift172
Protein
domains
InterPro ID Description
IPR001680 WD40 repeat
IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
IPR011046 WD40 repeat-like-containing domain
IPR015943 WD40/YVTN repeat-like-containing domain
IPR019781 WD40 repeat, subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:65500 Pazour GJ et al., "Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella" J Cell Biol 2000 Oct 30;151(3):709-18
(Latest) J:156426 Howard PW et al., "Generation of mice with a conditional allele for Ift172." Transgenic Res 2010 Feb;19(1):121-6
All references(14)
Other
accession IDs
MGI:1914911

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory