About   Help   FAQ
Tour our new Quick Search
Lrp2 Gene Detail
 Symbol
Name
ID
Lrp2
low density lipoprotein receptor-related protein 2
MGI:95794

Nomenclature History
Synonyms D230004K18Rik, Gp330, Megalin
Genetic Map
Chromosome 2
40.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 11)

Sequence Map
Chr2:69262397-69424122 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; pig, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Lrp2 ± 2 cM)
Protein SuperFamily: LDL receptor-related protein
TreeFam: TF315253
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000012988 VEGA Gene Model | MGI Sequence Detail 161726 C57BL/6J ± Kb
transcript NM_001081088 RefSeq | MGI Sequence Detail 15467 -
polypeptide A2ARV4 UniProt | EBI | MGI Sequence Detail 4660 Not Applicable
For the selected sequences
All sequences(36)
Alleles
and
phenotypes 		All alleles(25) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(21) Chemically induced(1)
Homozygotes for a targeted null mutation exhibit lung and kidney epithelial defects, impaired B12 uptake, reduced proliferation of the neuroepithelium resulting in lack of olfactory bulbs, forebrain fusions, ventricular defects, and perinatal lethality.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(1158 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cell proliferation, endocytosis...
Component apical part of cell, apical plasma membrane...
Function calcium ion binding, protein binding...
External Resources: FuncBase
Expression Literature Summary: (19 records)
Data Summary: Assays (4)    Results (8)    Tissues (4)    Images (2)
Theiler Stages: 9,19,24,26
  Assay Type Assays   Results
      Immunohistochemistry 4   8
cDNA source data(123)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(127) Genomic(1) cDNA(125) Primer pair(1) Antibodies(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000027070
DoTS DT.530178, DT.91349072, DT.94166164, DT.97389734
Consensus CDS Project CCDS38135.1
UniGene 23847
DFCI TC1608935, TC1655996, TC1677693, TC1703921
NIA Mouse Gene Index U022710
Entrez Gene 14725
VEGA Gene Model OTTMUSG00000012988
International Mouse Knockout Project Status Lrp2
Protein
domains
InterPro ID Description
IPR000033 Low-density lipoprotein receptor, class B (YWTD) repeat
IPR000152 EGF-type aspartate/asparagine hydroxylation site
IPR000742 EGF-like, type 3
IPR001881 EGF-like calcium-binding
IPR002172 Low density lipoprotein-receptor, class A (cysteine-rich) repeat
IPR006210 EGF-like
IPR011042 Six-bladed beta-propeller, TolB-like
IPR013032 EGF-like region, conserved site
IPR013091 EGF calcium-binding
IPR018097 EGF-like calcium-binding, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:14575 Xia YR et al., "Mapping of the glycoprotein 330 (Gp330) gene to mouse chromosome 2." Genomics 1993 Sep;17(3):780-1
(Latest) J:151683 Parreira KS et al., "Expression patterns of the aquaporin gene family during renal development: influence of genetic variability." Pflugers Arch 2009 Aug;458(4):745-59
All references(69)
Other
accession IDs 		MGD-MRK-10218, MGI:2138891, MGI:2139361, MGI:2444234
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory