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Fli1 Gene Detail
 Symbol
Name
ID
Fli1
Friend leukemia integration 1
MGI:95554


Nomenclature History
Synonyms EWSR2, Fli-1, SIC-1, Sic1
Genetic Map
Chromosome 9
16.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 21)

Sequence Map
Chr9:32229793-32348953 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Fli1 ± 2 cM)
Protein SuperFamily: transcription factor erg
TreeFam: TF350537
Sequences
Representative Sequences Length Strain/Species Flank
genomic 14247 NCBI Gene Model | MGI Sequence Detail 119161 C57BL/6J ± Kb
transcript NM_008026 RefSeq | MGI Sequence Detail 3087 C57BL/6
polypeptide P26323 UniProt | EBI | MGI Sequence Detail 452 Not Applicable
For the selected sequences
All sequences(20)
Alleles
and
phenotypes
All alleles(6) : Targeted, knock-out(5) Gene trapped(1)
Associated Human Diseases (2)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(2) SNPs within 2kb(923 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process blood circulation, cellular process...
Component nucleus
Function DNA binding, sequence-specific DNA binding...
External Resources: FuncBase
Expression Literature Summary: (11 records)
Data Summary: Assays (8)    Results (106)    Tissues (96)    Images (8)
Theiler Stages: 13,15,16,17,19,21,22,23,25,28
  Assay Type Assays   Results
      Western blot 1   3
      RT-PCR 2   6
      In situ reporter (knock in) 1   3
      RNA in situ 4   94
cDNA source data(29)
External Resources: GEO  ArrayExpress 
Molecular
reagents
All nucleic(45) Genomic(14) cDNA(29) Primer pair(2) Antibodies(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000016087
DoTS DT.485049
Consensus CDS Project CCDS40571.1
UniGene 258908
DFCI TC1577491
NIA Mouse Gene Index U030653
Entrez Gene 14247
International Mouse Knockout Project Status Fli1
Protein
domains
InterPro ID Description
IPR000418 Ets
IPR003118 Sterile alpha motif/pointed
IPR010993 Sterile alpha motif homology
IPR011991 Winged helix repressor DNA-binding
IPR013761 Sterile alpha motif-type
Graphical View of Protein Domain Structure
References
(Earliest) J:10321 Ben-David Y et al., "Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus." Proc Natl Acad Sci U S A 1990 Feb;87(4):1332-6
(Latest) J:151966 Kruse EA et al., "Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage." Proc Natl Acad Sci U S A 2009 Aug 18;106(33):13814-9
All references(49)
Other
accession IDs
MGD-MRK-9824, MGD-MRK-9825

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory