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Bai2 Gene Detail
 Symbol
Name
ID
Bai2
brain-specific angiogenesis inhibitor 2
MGI:2451244


Nomenclature History
Genetic Map
Chromosome 4
Syntenic
 
Mapping data( 1)
Sequence Map
Chr4:129662114-129699877 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: brain-specific angiogenesis inhibitor
TreeFam: TF331634
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000009519 VEGA Gene Model | MGI Sequence Detail 37764 C57BL/6J ± Kb
transcript NM_173071 RefSeq | MGI Sequence Detail 5104 C57BL/6
polypeptide Q8CGM1 UniProt | EBI | MGI Sequence Detail 1561 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes
All alleles(1) : Targeted, other(1)
Mice homozygous for disruptions in this gene show a lessening of depression like behavior.
Polymorphisms SNPs within 2kb(161 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway...
Component integral to membrane, membrane...
Function brain-specific angiogenesis inhibitor activity, G-protein coupled receptor activity...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (3)    Results (136)    Tissues (95)    Images (71)
Theiler Stages: 26,28
  Assay Type Assays   Results
      RT-PCR 1   38
      In situ reporter (knock in) 1   89
      Northern blot 1   9
cDNA source data(56)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(58) Genomic(1) cDNA(56) Primer pair(1)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000028782
UniGene 262241
DFCI TC1579874, TC1596617
Entrez Gene 230775
VEGA Gene Model OTTMUSG00000009519
International Mouse Knockout Project Status Bai2
Protein
domains
InterPro ID Description
IPR000203 GPS domain
IPR000832 GPCR, family 2, secretin-like
IPR000884 Thrombospondin, type 1 repeat
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR008077 GPCR, family 2, brain-specific angiogenesis inhibitor
IPR017981 GPCR, family 2-like
Graphical View of Protein Domain Structure
References
(Earliest) J:77162 Kee HJ et al., "Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis." J Cereb Blood Flow Metab 2002 Sep;22(9):1054-67
(Latest) J:105522 Jeong BC et al., "Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor." FEBS Lett 2006 Jan 23;580(2):669-76
All references(5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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