Symbol
Name
ID
|
|
|
STS
|
D1Mit217
|
|
Synonyms
|
En-1, engrailed-1, Mo-en.1
|
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Genetic Map
|
|
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Sequence Map
|
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Mammalian
homology
|
|
|
Sequences
|
All sequences(18)
|
Alleles
and
phenotypes
|
All alleles(15) :
Targeted, knock-out(1)
Targeted, other(14)
| Mutant homozygotes usually die within 24 hours of birth. Mutants exhibit nervous system defects, including a lack of most of the colliculi, cerebellum, and the third and fourth cranial nerves in some lines. Skeletal anomalies have also been described. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
|
|
Polymorphisms
|
RFLP(8)
SNPs within 2kb(34 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (207 records)
Data Summary:
Assays (42)
Results (231)
Tissues (119)
Images (87)
Theiler Stages: 12,13,14,15,16,17,18,19,20,21,22,23,24,25,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
4 |
|
54 |
| |
In situ reporter (knock in) |
3 |
|
15 |
| |
RNA in situ |
22 |
|
80 |
| |
Immunohistochemistry |
9 |
|
53 |
| |
Northern blot |
4 |
|
29 |
cDNA source data(19)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(38)
Genomic(5)
cDNA(20)
Primer pair(5)
Other(8)
Antibodies(5)
Microarray probesets(2)
|
Other database
links
|
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Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:8126
Joyner AL et al.,
"Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene."
Cell 1985 Nov;43(1):29-37
(Latest)
J:156172
Marklund U et al.,
"Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression."
Development 2010 Feb;137(3):437-45
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All references(281)
|
Other
accession IDs
|
MGD-MRK-12340, MGD-MRK-9497, MGD-MRK-9499
|
Analysis Tools
MGI BioMart
