Symbol
Name
ID
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(24)
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Alleles
and
phenotypes
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All alleles(1) :
Targeted, knock-out(1)
| Homozygous null mutants are male sterile, failing to produce mature spermatozoa; peripheral nerves are abnormal, with thin and disorganized perineurial sheaths. High penetrance of pseudohermaphroditism observed on some mixed backgrounds. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
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Polymorphisms
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RFLP(1)
SNPs within 2kb(19 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (45 records)
Data Summary:
Assays (6)
Results (146)
Tissues (64)
Images (5)
Theiler Stages: 18,20,21,22,23,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
4 |
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142 |
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RNA in situ |
1 |
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3 |
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Northern blot |
1 |
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1 |
cDNA source data(6)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
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All nucleic(14)
Genomic(2)
cDNA(6)
Primer pair(3)
Other(3)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR000320 |
Hedgehog, N-terminal signaling domain |
| IPR001657 |
Peptidase C46, hedgehog protein |
| IPR001767 |
Peptidase C46, hedgehog protein, hint region |
| IPR003586 |
Hedgehog/intein hint domain, C-terminal |
| IPR003587 |
Hedgehog/intein hint, N-terminal |
| IPR006141 |
Intein splicing site |
| IPR009045 |
Hedgehog/DD-peptidase, zinc-binding motif |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:16386
Echelard Y et al.,
"Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity."
Cell 1993 Dec 31;75(7):1417-30
(Latest)
J:152858
Garcia-Ortiz JE et al.,
"Foxl2 functions in sex determination and histogenesis throughout mouse ovary development."
BMC Dev Biol 2009;9():36
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All references(63)
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Other
accession IDs
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MGD-MRK-8842, MGI:2146288
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