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Erap1 Gene Detail
 Symbol
Name
ID
Erap1
endoplasmic reticulum aminopeptidase 1
MGI:1933403


Nomenclature History
Synonyms Arts1, ERAAP, PILSAP
Genetic Map
Chromosome 13
cytoband C1
 
Mapping data( 2)
Sequence Map
Chr13:74777320-74829323 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: membrane alanyl aminopeptidase
TreeFam: TF300395
Sequences
Representative Sequences Length Strain/Species Flank
genomic 80898 NCBI Gene Model | MGI Sequence Detail 52004 C57BL/6J ± Kb
transcript NM_030711 RefSeq | MGI Sequence Detail 4014 C57BL/6
polypeptide Q9EQH2 UniProt | EBI | MGI Sequence Detail 930 Not Applicable
For the selected sequences
All sequences(18)
Alleles
and
phenotypes
All alleles(8) : Targeted, knock-out(4) Targeted, other(4)
Mice homozygous for a targeted mutation may exhibit extramedullary hematopoiesis of the spleen, thymus hyperplasia, or enlarged kidneys at older ages.
Polymorphisms SNPs within 2kb(218 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(16)
Process immune response, positive regulation of angiogenesis...
Component cytoplasm, endoplasmic reticulum...
Function aminopeptidase activity, hydrolase activity...
External Resources: MouseFunc
Expression Literature Summary: (1 records)
Data Summary: Assays (2)    Results (110)    Tissues (64)    Images (31)
Theiler Stages: 28
  Assay Type Assays   Results
      RT-PCR 1   38
      In situ reporter (knock in) 1   72
cDNA source data(75)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(77) cDNA(76) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000021583
UniGene 83526
Entrez Gene 80898
International Mouse Knockout Project Status Erap1
Protein
domains
InterPro ID Description
IPR001930 Peptidase M1, membrane alanine aminopeptidase
IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site
IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:68745 Miyashita H et al., "A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis." Blood 2002 May 1;99(9):3241-9
(Latest) J:137849 Blanchard N et al., "Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum." Nat Immunol 2008 Aug;9(8):937-44
All references(14)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory