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Ubr5 Gene Detail
 Symbol
Name
ID
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
MGI:1918040


Nomenclature History
Synonyms 4432411E13Rik, Edd1, mKIAA0896
Genetic Map
Chromosome 15
Syntenic
 
Mapping data( 2)
Sequence Map
Chr15:37897083-37978898 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF314406
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000037487 Ensembl Gene Model | MGI Sequence Detail 81816 C57BL/6J ± Kb
transcript NM_001081359 RefSeq | MGI Sequence Detail 9790 C57BL/6
polypeptide Q80TP3 UniProt | EBI | MGI Sequence Detail 2792 Not Applicable
For the selected sequences
All sequences(46)
Alleles
and
phenotypes
All alleles(57) : Targeted, other(1) Gene trapped(56)
Homozygous null mice display embryonic lethality during organogenesis, impaired growth of the allantois, failure or impairment of chorioallantoic fusion, impaired angiogenesis in the yolk sac and allantois, decreased cell proliferation, and increased apoptosis.
Polymorphisms SNPs within 2kb(254 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process modification-dependent protein catabolic process, protein modification process...
Component intracellular, nucleus...
Function acid-amino acid ligase activity, ligase activity...
External Resources: FuncBase
Expression Literature Summary: (1 records)
cDNA source data(9)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000037487
DoTS DT.101394920, DT.101394923, DT.101739157, DT.495135, DT.91588835, DT.97379568, DT.99844589
DFCI TC1573380, TC1588239, TC1605732, TC1616786, TC1626988, TC1664148
NIA Mouse Gene Index U036111
Entrez Gene 70790
International Mouse Knockout Project Status Ubr5
Protein
domains
InterPro ID Description
IPR000569 HECT
IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
IPR003126 Zinc finger, N-recognin
IPR013993 Zinc finger, N-recognin, metazoa
Graphical View of Protein Domain Structure
References
(Earliest) J:60984 Ko MS et al., "Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development." Development 2000 Apr;127(8):1737-49
(Latest) J:145887 Tasaki T et al., "The substrate recognition domains of the N-end rule pathway." J Biol Chem 2009 Jan 16;284(3):1884-95
All references(13)
Other
accession IDs
MGI:2146233, MGI:2146275

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory