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Bdkrb1 Gene Detail
 Symbol
Name
ID
Bdkrb1
bradykinin receptor, beta 1
MGI:88144

Nomenclature History
Synonyms B1R, kinin B1
Genetic Map
Chromosome 12
cytoband F1
 
Mapping data( 1)
Sequence Map
Chr12:106842301-106843638 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rabbit, European; rat    (Mammalian Orthology)
Protein SuperFamily: bradykinin receptor
TreeFam: TF330024
Sequences
Representative Sequences Length Strain/Species Flank
genomic 12061 NCBI Gene Model | MGI Sequence Detail 1338 C57BL/6J ± Kb
transcript NM_007539 RefSeq | MGI Sequence Detail 1338 129X1/SvJ
polypeptide Q61125 UniProt | EBI | MGI Sequence Detail 334 Not Applicable
For the selected sequences
All sequences(11)
Alleles
and
phenotypes 		All alleles(6) : Targeted, knock-out(5) Targeted, other(1)
Mice homozygous for one null allele display hypoalgesia and altered inflammatory responses while those homozygous for another are reported to have a normal phenotype.
Phenotype Images (1)  
Polymorphisms SNPs within 2kb(62 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process G-protein coupled receptor protein signaling pathway, response to lipopolysaccharide...
Component integral to membrane, membrane...
Function bradykinin receptor activity, G-protein coupled receptor activity...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (1)    Results (35)    Tissues (35)    Images (1)
Theiler Stages: 28
  Assay Type Assays   Results
      RT-PCR 1   35
cDNA source data(1)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(4) Genomic(2) cDNA(1) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000041347
DoTS DT.91594807
Consensus CDS Project CCDS26155.1
UniGene 377078
DFCI TC1599572
Entrez Gene 12061
International Mouse Knockout Project Status Bdkrb1
Protein
domains
InterPro ID Description
IPR000276 7TM GPCR, rhodopsin-like
IPR000496 Bradykinin receptor
IPR001186 B1 bradykinin receptor
IPR017452 GPCR, rhodopsin-like superfamily
Graphical View of Protein Domain Structure
References
(Earliest) J:16469 McIntyre P et al., "Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity [published erratum appears in Mol Pharmacol 1994 Mar;45(3):561]" Mol Pharmacol 1993 Aug;44(2):346-55
(Latest) J:154967 Bulut OP et al., "Ontogeny of bradykinin B1 receptors in the mouse kidney." Pediatr Res 2009 Nov;66(5):519-23
All references(27)
Other
accession IDs 		MGD-MRK-1533
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory