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Gsk3b Gene Detail
 Symbol
Name
ID
Gsk3b
glycogen synthase kinase 3 beta
MGI:1861437

Nomenclature History
Synonyms 7330414F15Rik, 8430431H08Rik, GSK-3, GSK-3beta, GSK3
Genetic Map
Chromosome 16
cytoband B4
 
Mapping data( 3)
Sequence Map
Chr16:38089087-38246170 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: kinase-related transforming protein
TreeFam: TF101104
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016276 VEGA Gene Model | MGI Sequence Detail 157084 C57BL/6J ± Kb
transcript NM_019827 RefSeq | MGI Sequence Detail 8298 C57BL/6
polypeptide Q9WV60 UniProt | EBI | MGI Sequence Detail 420 Not Applicable
For the selected sequences
All sequences(36)
Alleles
and
phenotypes 		All alleles(96) : Targeted, knock-out(3) Targeted, other(4) Gene trapped(89)
Mice homozygous for disruptions in this gene may die embryonically around mid-gestation or neonatally. When mice die neonatally, cleft palate and sternum are present.
Phenotype Images (2)  
Polymorphisms SNPs within 2kb(665 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process anti-apoptosis, cell proliferation...
Component cell soma, cytoplasm...
Function ATP binding, beta-catenin binding...
External Resources: FuncBase
Expression Literature Summary: (33 records)
Data Summary: Assays (10)    Results (215)    Tissues (123)    Images (115)
Theiler Stages: 1,2,3,5,20,21,28
  Assay Type Assays   Results
      Western blot 5   42
      RT-PCR 1   38
      In situ reporter (knock in) 1   131
      RNA in situ 1   2
      Immunohistochemistry 2   2
cDNA source data(15)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(18) cDNA(16) Primer pair(1) Other(1) Antibodies(6)
Microarray probesets(2)
Other database
links
EC 2.7.11.26
Ensembl Gene Model ENSMUSG00000022812
Consensus CDS Project CCDS28163.1
DFCI TC1579305, TC1616105, TC1659348, TC1661346
Entrez Gene 56637
VEGA Gene Model OTTMUSG00000016276
International Mouse Knockout Project Status Gsk3b
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:135482 Diehl JA et al., "Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization." Genes Dev 1998 Nov 15;12(22):3499-511
(Latest) J:154623 Kim WY et al., "GSK-3 is a master regulator of neural progenitor homeostasis." Nat Neurosci 2009 Nov;12(11):1390-7
All references(125)
Other
accession IDs 		MGI:1914056, MGI:1925394, MGI:2146721
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory