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Chst3 Gene Detail
 Symbol
Name
ID
Chst3
carbohydrate (chondroitin 6/keratan) sulfotransferase 3
MGI:1858224


Nomenclature History
Synonyms C6ST, C6ST-1, GST-0
Genetic Map
Chromosome 10
cytoband C
 
Mapping data( 2)
Sequence Map
Chr10:59644282-59651455 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: carbohydrate sulfotransferase
TreeFam: TF342871
Sequences
Representative Sequences Length Strain/Species Flank
genomic 53374 NCBI Gene Model | MGI Sequence Detail 7174 C57BL/6J ± Kb
transcript NM_016803 RefSeq | MGI Sequence Detail 6129 C57BL/6
polypeptide O88199 UniProt | EBI | MGI Sequence Detail 472 Not Applicable
For the selected sequences
All sequences(20)
Alleles
and
phenotypes
All alleles(7) : Targeted, knock-out(1) Targeted, other(1) Gene trapped(5)
Homozygous mutation of this gene results in significantly reduced numbers of naive T lymphocytes in the spleen at 5-6 weeks of age. Brain development and morphology is normal in mutant animals but for some alleles behavioral abnormalities are seen.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(72 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process carbohydrate metabolic process
Component Golgi apparatus, Golgi membrane...
Function chondroitin 6-sulfotransferase activity, sulfotransferase activity...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (4)    Results (140)    Tissues (85)    Images (64)
Theiler Stages: 21,28
  Assay Type Assays   Results
      RT-PCR 2   40
      In situ reporter (knock in) 1   96
      RNA in situ 1   4
cDNA source data(17)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(20) cDNA(17) Primer pair(3)
Microarray probesets(2)
Other database
links
EC 2.8.2.17
Ensembl Gene Model ENSMUSG00000057337
DoTS DT.101198690, DT.488506, DT.87048237
Consensus CDS Project CCDS23871.1
UniGene 12866
DFCI TC1598793, TC1602116, TC1644862, TC1704984
NIA Mouse Gene Index U031827
Entrez Gene 53374
International Mouse Knockout Project Status Chst3
Protein
domains
InterPro ID Description
IPR000863 Sulfotransferase domain
IPR016469 Carbohydrate sulfotransferase
Graphical View of Protein Domain Structure
References
(Earliest) J:47830 Uchimura K et al., "Mouse chondroitin 6-sulfotransferase: molecular cloning, characterization and chromosomal mapping." Glycobiology 1998 May;8(5):489-96
(Latest) J:133424 Akita K et al., "Expression of multiple chondroitin/dermatan sulfotransferases in the neurogenic regions of the embryonic and adult central nervous system implies that complex chondroitin sulfates have a role in neural stem cell maintenance." Stem Cells 2008 Mar;26(3):798-809
All references(7)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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