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Crim1 Gene Detail
 Symbol
Name
ID
Crim1
cysteine rich transmembrane BMP regulator 1 (chordin like)
MGI:1354756


Nomenclature History
Genetic Map
Chromosome 17
Syntenic
 
Mapping data( 2)
Sequence Map
Chr17:78596408-78773654 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
TreeFam: TF106451
Sequences
Representative Sequences Length Strain/Species Flank
genomic 50766 NCBI Gene Model | MGI Sequence Detail 177247 C57BL/6J ± Kb
transcript NM_015800 RefSeq | MGI Sequence Detail 3502 C57BL/6
polypeptide Q9JLL0 UniProt | EBI | MGI Sequence Detail 1037 Not Applicable
For the selected sequences
All sequences(24)
Alleles
and
phenotypes
All alleles(2) : Gene trapped(2)
Mutations in this locus cause perinatal lethality, syndactyly, and eye and kidney abnormalities.
Polymorphisms SNPs within 2kb(400 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process regulation of cell growth
Component extracellular region, integral to membrane...
Function enzyme inhibitor activity, insulin-like growth factor binding...
External Resources: FuncBase
Expression Literature Summary: (12 records)
Data Summary: Assays (2)    Results (69)    Tissues (52)    Images (25)
Theiler Stages: 11,13,14,15,16,17,18,19,20,21,22,23,25
  Assay Type Assays   Results
      RNA in situ 1   63
      Northern blot 1   6
cDNA source data(53)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(53) cDNA(53)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024074
DoTS DT.102550336, DT.484706
Consensus CDS Project CCDS28976.1
UniGene 311912
DFCI TC1583769, TC1704594
NIA Mouse Gene Index U018233
Entrez Gene 50766
International Mouse Knockout Project Status Crim1
Protein
domains
InterPro ID Description
IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR001007 von Willebrand factor, type C
IPR004094 Proteinase inhibitor I15, antistasin-like
IPR011061 Proteinase inhibitor I14/I15, hirudin/antistatin
IPR018112 Proteinase inhibitor I15, antistasin
Graphical View of Protein Domain Structure
References
(Earliest) J:60432 Kolle G et al., "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis." Mech Dev 2000 Feb;90(2):181-93
(Latest) J:152946 Sferruzzi-Perri AN et al., "Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice." Biol Reprod 2009 Jul;81(1):207-21
All references(17)
Other
accession IDs
MGI:2146965

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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