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Nr2f2 Gene Detail
 Symbol
Name
ID
Nr2f2
nuclear receptor subfamily 2, group F, member 2
MGI:1352452

Nomenclature History
Synonyms 9430015G03Rik, Aporp1, ARP-1, COUP-TF2, COUP-TFII, EAR3, Tcfcoup2
Genetic Map
Chromosome 7
33.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 7)

Sequence Map
Chr7:77496832-77511621 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Nr2f2 ± 2 cM)
Protein SuperFamily: retinoic X receptor-like nuclear receptor
TreeFam: TF352097
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000023060 VEGA Gene Model | MGI Sequence Detail 14790 C57BL/6J ± Kb
transcript NM_009697 RefSeq | MGI Sequence Detail 4216 C57BL/6
polypeptide P43135 UniProt | EBI | MGI Sequence Detail 414 Not Applicable
For the selected sequences
All sequences(25)
Alleles
and
phenotypes 		All alleles(5) : Targeted, knock-out(2) Targeted, other(3)
Homozygotes for a targeted null mutation exhibit impaired angiogenesis and heart development with hemorrhagic brains and hearts, and die around embryonic day 10. About 5% of heterozygotes share the hemorrhagic phenotype at embryonic day 9.5.
Polymorphisms RFLP(2) SNPs within 2kb(43 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process anterior/posterior pattern formation, blood vessel morphogenesis...
Component nucleus
Function DNA binding, ligand-dependent nuclear receptor activity...
External Resources: FuncBase
Expression Literature Summary: (46 records)
Data Summary: Assays (18)    Results (225)    Tissues (196)    Images (44)
Theiler Stages: 2,3,4,5,9,11,13,15,17,19,21,22,23,24,26,28
  Assay Type Assays   Results
      Western blot 1   1
      RT-PCR 2   19
      RNA in situ 10   195
      Immunohistochemistry 2   7
      Northern blot 1   1
      RNase protection 2   2
cDNA source data(16)
External Resources: GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(28) Genomic(5) cDNA(17) Primer pair(3) Other(3) Antibodies(2)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000030551
Consensus CDS Project CCDS21358.1, CCDS21359.1
DFCI TC1576930, TC1588743, TC1603714, TC1665055
NIA Mouse Gene Index U028699
Entrez Gene 11819
VEGA Gene Model OTTMUSG00000023060
International Mouse Knockout Project Status Nr2f2
Protein
domains
InterPro ID Description
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003068 Transcription factor COUP
IPR008946 Nuclear hormone receptor, ligand-binding
IPR013088 Zinc finger, NHR/GATA-type
IPR013629 Zinc finger, C4-type, C-terminal domain
Graphical View of Protein Domain Structure
References
(Earliest) J:18563 Qiu Y et al., "Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon." Proc Natl Acad Sci U S A 1994 May 10;91(10):4451-5
(Latest) J:153655 Satoh S et al., "The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors." J Neurosci 2009 Oct 7;29(40):12401-11
All references(69)
Other
accession IDs 		MGD-MRK-18615, MGD-MRK-32408, MGI:101803, MGI:2444514
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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