Symbol
Name
ID
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Adamts5
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
MGI:1346321
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Nomenclature History
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Synonyms
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9530092O11Rik, ADAM-TS5
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(33)
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Alleles
and
phenotypes
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All alleles(6) :
Targeted, knock-out(2)
Targeted, other(3)
Gene trapped(1)
| Mice homozygous for one null allele exhibit a significant reduction in cartilage degradation after induction of osteoarthritis whereas those homozygous for another show no affect. |
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Polymorphisms
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RFLP(1)
SNPs within 2kb(210 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
|
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Expression
|
Literature Summary: (10 records)
Data Summary:
Assays (7)
Results (244)
Tissues (179)
Images (94)
Theiler Stages: 10,13,15,17,18,20,22,23,25,26,28
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Assay Type |
Assays |
|
Results |
| |
RT-PCR |
2 |
|
54 |
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In situ reporter (knock in) |
1 |
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111 |
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RNA in situ |
3 |
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75 |
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Northern blot |
1 |
|
4 |
cDNA source data(16)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
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All nucleic(18)
cDNA(16)
Primer pair(2)
Microarray probesets(3)
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Other database
links
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Protein
domains
|
Graphical View
of Protein Domain Structure
|
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References
|
(Earliest)
J:56831
Abbaszade I et al.,
"Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family."
J Biol Chem 1999 Aug 13;274(33):23443-50
(Latest)
J:148803
McCulloch DR et al.,
"Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues."
Gene Expr Patterns 2009 Feb 27;():
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All references(19)
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Other
accession IDs
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MGI:1925767, MGI:2146445
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