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Sufu Gene Detail
 Symbol
Name
ID
Sufu
suppressor of fused homolog (Drosophila)
MGI:1345643


Nomenclature History
Synonyms 2810026F04Rik, Su(Fu)
Genetic Map
Chromosome 19
47.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr19:46471386-46563294 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Sufu ± 2 cM)
Protein SuperFamily: suppressor of fused protein
TreeFam: TF324548
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000030508 VEGA Gene Model | MGI Sequence Detail 91909 C57BL/6J ± Kb
transcript NM_015752 RefSeq | MGI Sequence Detail 2359 C57BL/6
polypeptide Q9Z0P7 UniProt | EBI | MGI Sequence Detail 484 Not Applicable
For the selected sequences
All sequences(46)
Alleles
and
phenotypes
All alleles(20) : Targeted, knock-out(2) Gene trapped(18)
Targeted disruption results in mid-gestation lethality, embryonic growth retardation, incomplete embryo turning, open neural tube, abnormal somite development, left-right asymmetry defects resulting in cardiac looping, and hemorrhage in the diencephalon.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(460 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cytoplasmic sequestering of transcription factor, determination of left/right symmetry...
Component cilium, cytoplasm...
Function beta-catenin binding, protein binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (11 records)
Data Summary: Assays (3)    Results (61)    Tissues (52)
Theiler Stages: 13,15,17,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      RNA in situ 1   43
      Northern blot 2   18
cDNA source data(12)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000025231
DoTS DT.40157788, DT.527806
Consensus CDS Project CCDS29879.1, CCDS38008.1
DFCI TC1580308, TC1594209, TC1598032, TC1648899
NIA Mouse Gene Index U019526
Entrez Gene 24069
VEGA Gene Model OTTMUSG00000030508
International Mouse Knockout Project Status Sufu
Protein
domains
InterPro ID Description
IPR007768 Suppressor of fused-like
IPR016591 Suppressor of fused protein
IPR020941 Suppressor of fused domain
Graphical View of Protein Domain Structure
References
(Earliest) J:56940 Pearse RV 2nd et al., "Vertebrate homologs of Drosophila suppressor of fused interact with the gli family of transcriptional regulators." Dev Biol 1999 Aug 15;212(2):323-36
(Latest) J:151950 Hyman JM et al., "Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade." Proc Natl Acad Sci U S A 2009 Aug 18;106(33):14132-7
All references(22)
Other
accession IDs
MGI:1919902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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