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Hhip Gene Detail
 Symbol
Name
ID
Hhip
Hedgehog-interacting protein
MGI:1341847

Nomenclature History
Synonyms Hhip1, Hip, Hip1
Genetic Map
Chromosome 8
40.0 cM, cytoband C3
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr8:82490014-82581905 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Hhip ± 2 cM)
TreeFam: TF329059
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000031006 VEGA Gene Model | MGI Sequence Detail 91892 C57BL/6J ± Kb
transcript NM_020259 RefSeq | MGI Sequence Detail 9094 C57BL/6
polypeptide Q7TN16 UniProt | EBI | MGI Sequence Detail 700 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes 		All alleles(2) : Targeted, other(1) Gene trapped(1)
Polymorphisms SNPs within 2kb(257 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process dorsal/ventral pattern formation, lung development...
Component cell surface, extracellular region...
Function catalytic activity, protein binding...
External Resources: FuncBase
Expression Literature Summary: (25 records)
Data Summary: Assays (9)    Results (98)    Tissues (45)    Images (18)
Theiler Stages: 17,18,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 4   66
      In situ reporter (knock in) 1   14
      RNA in situ 4   18
cDNA source data(16)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(23) cDNA(17) Primer pair(4) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000064325
DoTS DT.60104243
Consensus CDS Project CCDS22440.1
UniGene 254493
DFCI TC1586105, TC1601104
NIA Mouse Gene Index U029997, U255752
Entrez Gene 15245
VEGA Gene Model OTTMUSG00000031006
International Mouse Knockout Project Status Hhip
Protein
domains
InterPro ID Description
IPR000742 EGF-like, type 3
IPR006210 EGF-like
IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase
IPR011042 Six-bladed beta-propeller, TolB-like
IPR013032 EGF-like region, conserved site
IPR018143 Folate receptor, conserved region
Graphical View of Protein Domain Structure
References
(Earliest) J:53760 Chuang PT et al., "Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein." Nature 1999 Feb 18;397(6720):617-21
(Latest) J:147878 Gao B et al., "A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range." Nature 2009 Apr 30;458(7242):1196-200
All references(29)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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