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Adamts4 Gene Detail
 Symbol
Name
ID
Adamts4
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
MGI:1339949


Nomenclature History
Synonyms ADAM-TS4, aggrecanase-1
Genetic Map
Chromosome 1
92.3 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr1:173180552-173190768 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Adamts4 ± 2 cM)
TreeFam: TF331949
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021528 VEGA Gene Model | MGI Sequence Detail 10217 C57BL/6J ± Kb
transcript NM_172845 RefSeq | MGI Sequence Detail 3673 C57BL/6
polypeptide Q8BNJ2 UniProt | EBI | MGI Sequence Detail 833 Not Applicable
For the selected sequences
All sequences(31)
Alleles
and
phenotypes
All alleles(11) : Targeted, knock-out(2) Targeted, other(3) Gene trapped(6)
Homozygous mutant mice do not exhibit any morphological abnormalities. However, they do display impaired coordination and an increased susceptibility to pharmacologically induced seizures.
Polymorphisms RFLP(1) SNPs within 2kb(79 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process proteolysis
Component extracellular matrix, extracellular region...
Function hydrolase activity, metal ion binding...
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Assays (2)    Results (113)    Tissues (75)    Images (37)
Theiler Stages: 28
  Assay Type Assays   Results
      RT-PCR 1   38
      In situ reporter (knock in) 1   75
cDNA source data(39)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(41) cDNA(40) Primer pair(1)
Microarray probesets(2)
Other database
links
EC 3.4.24.82
Ensembl Gene Model ENSMUSG00000006403
DoTS DT.40142777, DT.97339683
Consensus CDS Project CCDS15485.1
UniGene 475917
DFCI TC1578134, TC1631971, TC1640871
NIA Mouse Gene Index U001081
Entrez Gene 240913
VEGA Gene Model OTTMUSG00000021528
International Mouse Knockout Project Status Adamts4
Protein
domains
InterPro ID Description
IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR002870 Peptidase M12B, propeptide
IPR008085 Thrombospondin, type 1 repeat, subgroup
IPR010294 ADAM-TS Spacer 1
IPR013273 Peptidase M12B, ADAM-TS
Graphical View of Protein Domain Structure
References
(Earliest) J:55481 Tortorella MD et al., "Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins [see comments]" Science 1999 Jun 4;284(5420):1664-6
(Latest) J:155754 McCulloch DR et al., "ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression." Dev Cell 2009 Nov;17(5):687-98
All references(16)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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