Symbol
Name
ID
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Adamts4
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
MGI:1339949
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Nomenclature History
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Synonyms
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ADAM-TS4, aggrecanase-1
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(31)
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Alleles
and
phenotypes
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All alleles(11) :
Targeted, knock-out(2)
Targeted, other(3)
Gene trapped(6)
| Homozygous mutant mice do not exhibit any morphological abnormalities. However, they do display impaired coordination and an increased susceptibility to pharmacologically induced seizures. |
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Polymorphisms
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RFLP(1)
SNPs within 2kb(79 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
|
Literature Summary: (3 records)
Data Summary:
Assays (2)
Results (113)
Tissues (75)
Images (37)
Theiler Stages: 28
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Assay Type |
Assays |
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Results |
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RT-PCR |
1 |
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38 |
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In situ reporter (knock in) |
1 |
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75 |
cDNA source data(39)
External Resources:
Allen Brain Atlas
GEO
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Molecular
reagents
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All nucleic(41)
cDNA(40)
Primer pair(1)
Microarray probesets(2)
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Other database
links
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Protein
domains
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| InterPro ID |
Description |
| IPR000884 |
Thrombospondin, type 1 repeat |
| IPR001590 |
Peptidase M12B, ADAM/reprolysin |
| IPR002870 |
Peptidase M12B, propeptide |
| IPR006025 |
Peptidase M, neutral zinc metallopeptidases, zinc-binding site |
| IPR008085 |
Thrombospondin, type 1 repeat, subgroup |
| IPR010294 |
ADAM-TS Spacer 1 |
| IPR013273 |
Peptidase M12B, ADAM-TS |
| IPR018358 |
Disintegrin, conserved site |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:55481
Tortorella MD et al.,
"Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins [see comments]"
Science 1999 Jun 4;284(5420):1664-6
(Latest)
J:132583
Stankunas K et al.,
"Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis."
Dev Cell 2008 Feb;14(2):298-311
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All references(15)
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