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Cacna2d3 Gene Detail
 Symbol
Name
ID
Cacna2d3
calcium channel, voltage-dependent, alpha2/delta subunit 3
MGI:1338890


Nomenclature History
Synonyms alpha 2 delta-3
Genetic Map
Chromosome 14
cytoband B
 
Mapping data( 1)
Sequence Map
Chr14:29718133-30535050 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: voltage-dependent calcium channel fused subunit
TreeFam: TF315824
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000021991 Ensembl Gene Model | MGI Sequence Detail 816918 C57BL/6J ± Kb
transcript NM_009785 RefSeq | MGI Sequence Detail 3710 -
polypeptide Q9Z1L5 UniProt | EBI | MGI Sequence Detail 1091 Not Applicable
For the selected sequences
All sequences(11)
Alleles
and
phenotypes
All alleles(2) : Targeted, other(1) Gene trapped(1)
Mice homozygous for disruptions in this gene have a decreased startle reflex and occasional animals show increased aggression and hyperactivity.
Polymorphisms SNPs within 2kb(4699 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process calcium ion transport, ion transport...
Component integral to membrane, membrane...
Function calcium channel activity, calcium ion binding...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (3)    Results (95)    Tissues (54)    Images (12)
Theiler Stages: 25,28
  Assay Type Assays   Results
      RT-PCR 2   41
      In situ reporter (knock in) 1   54
cDNA source data(13)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(17) cDNA(13) Primer pair(2) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000021991
DoTS DT.87068382
UniGene 386754
DFCI TC1585796
NIA Mouse Gene Index U035350
Entrez Gene 12294
International Mouse Knockout Project Status Cacna2d3
Protein
domains
InterPro ID Description
IPR002035 von Willebrand factor, type A
IPR004010 Cache
IPR013608 VWA N-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:52012 Klugbauer N et al., "Molecular diversity of the calcium channel alpha2delta subunit." J Neurosci 1999 Jan 15;19(2):684-91
(Latest) J:119550 Harrell MD et al., "Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development." Physiol Genomics 2007 Feb 12;28(3):273-83
All references(3)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory