Dyrk1a MGI Mouse Gene Detail - MGI:1330299 - dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a

Dyrk1a Gene Detail

Symbol
Name
ID

Dyrk1a
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
MGI:1330299

Synonyms

2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, Mnbh

Genetic Map

Chromosome 16
68.3 cM
Detailed Genetic Map ± 1 cM

Mapping data( 8)

Sequence Map

Chr16:94791617-94916674 bp, + strand

(From VEGA annotation of NCBI Build 37)

VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian
homology

human; chimpanzee; cattle; dog, domestic; rat (Mammalian Orthology)

Comparative Map (Mouse/Human Dyrk1a ± 2 cM)

TreeFam: TF314624

Sequences

All sequences(47)

Alleles
and
phenotypes

All alleles(32) : Targeted, knock-out(1) Gene trapped(31)

Mice homozygous for a targeted deletion present a general embryonic growth delay and die during midgestation. Heterozygotes display reduced postnatal survival, postnatal growth retardation, microcephaly, behavioral and motor deficits, and altered neocortical pyramidal cell morphology.

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(506 from dbSNP Build 128)

Gene Ontology
(GO)
classifications

All GO classifications: (15 annotations)
Process	peptidyl-tyrosine phosphorylation, protein amino acid phosphorylation...
Component	nucleus
Function	ATP binding, kinase activity...
External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Assays (7) Results (119) Tissues (68) Images (5)
Theiler Stages: 13,15,17,20,22,23,26,28

Assay Type	Assays	Results
Western blot	1	3
RT-PCR	2	18
RNA in situ	4	98

cDNA source data(131)
External Resources: Allen Brain Atlas GENSAT GEO ArrayExpress

Molecular
reagents

All nucleic(143) Genomic(5) cDNA(131) Primer pair(5) Other(2) Antibodies(1)
Microarray probesets(4)

Other database
links

EC	2.7.12.1
Ensembl Gene Model	ENSMUSG00000022897
DoTS	DT.110720525, DT.110720549, DT.534324, DT.99855281
Consensus CDS Project	CCDS28350.1
UniGene	310973
DFCI	TC1582103, TC1627821, TC1687400, TC1693958, TC1697621
NIA Mouse Gene Index	U017413
Entrez Gene	13548
VEGA Gene Model	OTTMUSG00000028435
International Mouse Knockout Project Status	Dyrk1a

Protein
domains

InterPro ID	Description
IPR000719	Protein kinase, catalytic domain
IPR002290	Serine/threonine-protein kinase domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain
IPR017441	Protein kinase, ATP binding site
IPR017442	Serine/threonine-protein kinase-like domain

Graphical View of Protein Domain Structure

References

(Earliest) J:29230 Patil N et al., "A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation [see comments]" Nat Genet 1995 Oct;11(2):126-9
(Latest) J:156321 Lee Y et al., "Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis." J Biol Chem 2009 Nov 27;284(48):33343-51

All references(39)

Other
accession IDs

MGD-MRK-28072, MGD-MRK-38315, MGI:104780, MGI:109270, MGI:1196299, MGI:1277155, MGI:1923715

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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