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Lhx9 Gene Detail
 Symbol
Name
ID
Lhx9
LIM homeobox protein 9
MGI:1316721


Nomenclature History
Synonyms 3110009O07Rik, LH2B, Lhx9 alpha
Genetic Map
Chromosome 1
cytoband G-H2
 
Mapping data( 4)
Sequence Map
Chr1:140721763-140745153 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: homeotic protein LH-2
TreeFam: TF315442
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000022572 VEGA Gene Model | MGI Sequence Detail 23391 C57BL/6J ± Kb
transcript NM_001025565 RefSeq | MGI Sequence Detail 4924 C57BL/6
polypeptide Q9WUH2 UniProt | EBI | MGI Sequence Detail 397 Not Applicable
For the selected sequences
All sequences(39)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(1) Targeted, other(2)
Homozygotes for a targeted null mutation exhibit failed proliferation of the somatic cells of the genital ridge resulting in lack of discrete gonad formation, infertility in both sexes, and female-like genitalia in genetically male mice.
Polymorphisms SNPs within 2kb(104 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(17)
Process cell proliferation, female gonad development...
Component nucleus
Function DNA binding, metal ion binding...
External Resources: MouseFunc
Expression Literature Summary: (61 records)
Data Summary: Assays (13)    Results (314)    Tissues (160)    Images (35)
Theiler Stages: 15,17,18,19,20,21,22,24,28
  Assay Type Assays   Results
      RT-PCR 2   46
      RNA in situ 10   256
      Northern blot 1   12
cDNA source data(11)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(12) Primer pair(3) Other(2) Antibodies(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000019230
DoTS DT.101234375, DT.55233363, DT.55254467, DT.87072269, DT.94293332, DT.97394147
DFCI TC1586994, TC1598742, TC1599344, TC1705672, TC1714501
NIA Mouse Gene Index U021832, U063437
Entrez Gene 16876
VEGA Gene Model OTTMUSG00000022572
International Mouse Knockout Project Status Lhx9
Protein
domains
InterPro ID Description
IPR001356 Homeobox
IPR001781 Zinc finger, LIM-type
IPR012287 Homeodomain-related
IPR017970 Homeobox, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:50972 Lee KJ et al., "Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord." Genes Dev 1998 Nov 1;12(21):3394-407
(Latest) J:152710 Aldinger KA et al., "FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation." Nat Genet 2009 Sep;41(9):1037-42
All references(68)
Other
accession IDs
MGI:1920327, MGI:2138632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory