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Ugdh Gene Detail
 Symbol
Name
ID
Ugdh
UDP-glucose dehydrogenase
MGI:1306785


Nomenclature History
Synonyms Udpgdh
Genetic Map
Chromosome 5
38.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 1)

Sequence Map
Chr5:65804441-65827185 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ugdh ± 2 cM)
Protein SuperFamily: UDP-glucose/GDP-mannose dehydrogenase
TreeFam: TF105671
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000028398 VEGA Gene Model | MGI Sequence Detail 22745 C57BL/6J ± Kb
transcript NM_009466 RefSeq | MGI Sequence Detail 2461 FVB/N
polypeptide O70475 UniProt | EBI | MGI Sequence Detail 493 Not Applicable
For the selected sequences
All sequences(33)
Alleles
and
phenotypes
All alleles(27) : Gene trapped(26) Chemically induced(1)
Mutation of this gene results in developmental arrest during gastrulation with defects in endoderm and mesoderm migration.
Polymorphisms RFLP(1) SNPs within 2kb(97 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process gastrulation with mouth forming second, metabolic process...
Function binding, catalytic activity...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (2)    Results (98)    Tissues (98)    Images (14)
Theiler Stages: 11,19,22,23,25
  Assay Type Assays   Results
      RNA in situ 1   94
      Northern blot 1   4
cDNA source data(104)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(107) Genomic(1) cDNA(105) Primer pair(1)
Microarray probesets(2)
Pathways
colanic acid building blocks biosynthesis
galactose degradation II
UDP-D-xylose biosynthesis
vitamin C biosynthesis
Other database
links
EC 1.1.1.22
Ensembl Gene Model ENSMUSG00000029201
DoTS DT.532354, DT.91383671, DT.94310147
Consensus CDS Project CCDS19308.1
UniGene 344831
DFCI TC1572553, TC1612994
NIA Mouse Gene Index U026243
Entrez Gene 22235
VEGA Gene Model OTTMUSG00000028398
International Mouse Knockout Project Status Ugdh
Protein
domains
InterPro ID Description
IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation
IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal
IPR014028 UDP-glucose/GDP-mannose dehydrogenase, dimerisation and substrate-binding domain
IPR016040 NAD(P)-binding domain
IPR017476 Nucleotide sugar dehydrogenase
Graphical View of Protein Domain Structure
References
(Earliest) J:50095 Spicer AP et al., "Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes." J Biol Chem 1998 Sep 25;273(39):25117-24
(Latest) J:132583 Stankunas K et al., "Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis." Dev Cell 2008 Feb;14(2):298-311
All references(9)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory