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Ptch2 Gene Detail
 Symbol
Name
ID
Ptch2
patched homolog 2
MGI:1095405


Nomenclature History
Synonyms ptc2
Genetic Map
Chromosome 4
56.5 cM, cytoband C-D
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr4:116768680-116788706 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ptch2 ± 2 cM)
Protein SuperFamily: Drosophila membrane protein patched
TreeFam: TF106489
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000009923 VEGA Gene Model | MGI Sequence Detail 20027 C57BL/6J ± Kb
transcript NM_008958 RefSeq | MGI Sequence Detail 3549 C57BL/6
polypeptide O35595 UniProt | EBI | MGI Sequence Detail 1182 Not Applicable
For the selected sequences
All sequences(20)
Alleles
and
phenotypes
All alleles(12) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(9)
Male mice homozygous for a targeted gene disruption display anemia, abnormal red blood cells, enlarged spleens, extramedullary hematopoiesis, and an increased percentage of neutrophils. Most male mice homozygous for another allele display alopecia and skin lesions.
Polymorphisms SNPs within 2kb(156 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process epidermis development, hair cycle...
Component integral to membrane, membrane...
Function hedgehog receptor activity, receptor activity...
External Resources: FuncBase
Expression Literature Summary: (42 records)
Data Summary: Assays (5)    Results (114)    Tissues (82)    Images (56)
Theiler Stages: 19,21,22,28
  Assay Type Assays   Results
      RT-PCR 2   40
      In situ reporter (knock in) 1   58
      RNA in situ 2   16
cDNA source data(25)
External Resources: GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(32) Genomic(2) cDNA(25) Primer pair(2) Other(3)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000028681
DoTS DT.101720535, DT.485910
Consensus CDS Project CCDS18526.1
UniGene 287037
DFCI TC1597195, TC1675104
NIA Mouse Gene Index U004705
Entrez Gene 19207
VEGA Gene Model OTTMUSG00000009923
International Mouse Knockout Project Status Ptch2
Protein
domains
InterPro ID Description
IPR000731 Sterol-sensing 5TM box
IPR003392 Patched
IPR004766 Transmembrane receptor, patched
Graphical View of Protein Domain Structure
References
(Earliest) J:41710 Takabatake T et al., "Hedgehog and patched gene expression in adult ocular tissues." FEBS Lett 1997 Jun 30;410(2-3):485-9
(Latest) J:153743 Purcell P et al., "Temporomandibular joint formation requires two distinct hedgehog-dependent steps." Proc Natl Acad Sci U S A 2009 Oct 27;106(43):18297-302
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory