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Fzd4 Gene Detail
 Symbol
Name
ID
Fzd4
frizzled homolog 4 (Drosophila)
MGI:108520

Nomenclature History
Synonyms Fz4
Genetic Map
Chromosome 7
44.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 5)

Sequence Map
Chr7:96552894-96557912 bp, + strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Fzd4 ± 2 cM)
Protein SuperFamily: G protein-coupled receptor frizzled
TreeFam: TF317907
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000049791 Ensembl Gene Model | MGI Sequence Detail 5019 C57BL/6J ± Kb
transcript NM_008055 RefSeq | MGI Sequence Detail 3685 C57BL/6
polypeptide Q61088 UniProt | EBI | MGI Sequence Detail 537 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(1) Targeted, other(2)
Mice homozygous for disruptions in this gene display abnormalities in hearing, locomotion, retinal morphology and degeneration of the cerebellum.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(1) SNPs within 2kb(33 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway...
Component integral to membrane, membrane...
Function G-protein coupled receptor activity, non-G-protein coupled 7TM receptor activity...
External Resources: FuncBase
Expression Literature Summary: (25 records)
Data Summary: Assays (9)    Results (151)    Tissues (126)    Images (22)
Theiler Stages: 1,2,3,4,5,17,18,19,20,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 6   28
      RNA in situ 2   118
      Immunohistochemistry 1   5
cDNA source data(51)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(60) Genomic(1) cDNA(52) Primer pair(6) Other(1) Antibodies(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000049791
DoTS DT.486707, DT.529597
Consensus CDS Project CCDS21441.1
UniGene 86755
DFCI TC1581042
NIA Mouse Gene Index U042832
Entrez Gene 14366
International Mouse Knockout Project Status Fzd4
Protein
domains
InterPro ID Description
IPR000024 Frizzled cysteine-rich domain
IPR000539 Frizzled protein
IPR015526 Frizzled related
IPR017981 GPCR, family 2-like
IPR020067 Frizzled-like domain
IPR020068 Frizzled domain, subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:37068 Wang Y et al., "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled." J Biol Chem 1996 Feb 23;271(8):4468-76
(Latest) J:154020 Ye X et al., "Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization." Cell 2009 Oct 16;139(2):285-98
All references(38)
Other
accession IDs 		MGD-MRK-37564
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory