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Aldh7a1 Gene Detail
 Symbol
Name
ID
Aldh7a1
aldehyde dehydrogenase family 7, member A1
MGI:108186


Nomenclature History
Synonyms Atq1, D18Wsu181e
Genetic Map
Chromosome 18
29.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 7)

Sequence Map
Chr18:56686402-56721878 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Aldh7a1 ± 2 cM)
Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
TreeFam: TF300388
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000053644 Ensembl Gene Model | MGI Sequence Detail 35477 C57BL/6J ± Kb
transcript NM_001127338 RefSeq | MGI Sequence Detail 3105 C57BL/6
polypeptide Q9DBF1 UniProt | EBI | MGI Sequence Detail 511 Not Applicable
For the selected sequences
All sequences(30)
Alleles
and
phenotypes
All alleles(4) : Gene trapped(4)
Mice homozygous for disruptions in this gene display a normal phenotuype.
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(210 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process metabolic process, oxidation reduction...
Component mitochondrion
Function L-aminoadipate-semialdehyde dehydrogenase activity, oxidoreductase activity...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (2)    Results (99)    Tissues (95)    Images (19)
Theiler Stages: 11,22
  Assay Type Assays   Results
      RT-PCR 1   6
      RNA in situ 1   93
cDNA source data(204)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(208) cDNA(205) Primer pair(3)
Microarray probesets(4)
Pathways
putrescine degradation III
fatty acid α-oxidation
β-alanine biosynthesis I
L-lactaldehyde degradation (aerobic)
oxidative ethanol degradation I
Other database
links
EC 1.2.1.31
Ensembl Gene Model ENSMUSG00000053644
Consensus CDS Project CCDS29258.1
UniGene 30250
DFCI TC1572084, TC1583648, TC1707961
NIA Mouse Gene Index U058287
Entrez Gene 110695
International Mouse Knockout Project Status Aldh7a1
Protein
domains
InterPro ID Description
IPR015590 Aldehyde dehydrogenase
IPR016160 Aldehyde dehydrogenase, conserved site
IPR016161 Aldehyde/histidinol dehydrogenase
IPR016162 Aldehyde dehydrogenase, N-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:4717 Gill RK et al., "Identification of sequence elements in mouse calbindin-D28k gene that confer 1,25-dihydroxyvitamin D3- and butyrate-inducible responses." Proc Natl Acad Sci U S A 1993 Apr 1;90(7):2984-8
(Latest) J:145577 Levi BP et al., "Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems." Blood 2009 Feb 19;113(8):1670-80
All references(17)
Other
accession IDs
MGD-MRK-36424, MGD-MRK-37225, MGI:107847

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory