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Gpc3 Gene Detail
 Symbol
Name
ID
Gpc3
glypican 3
MGI:104903


Nomenclature History
Synonyms OCI-5
Genetic Map
Chromosome X
cytoband A3.3
 
Mapping data( 2)
Sequence Map
ChrX:49625603-49967127 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: glypican
TreeFam: TF105317
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000017333 VEGA Gene Model | MGI Sequence Detail 341525 C57BL/6J ± Kb
transcript NM_016697 RefSeq | MGI Sequence Detail 2272 C57BL/6
polypeptide Q8CFZ4 UniProt | EBI | MGI Sequence Detail 579 Not Applicable
For the selected sequences
All sequences(30)
Alleles
and
phenotypes
All alleles(30) : Targeted, knock-out(3) Gene trapped(27)
A gene trap mutation exibits neonatal lethality, embryonic overgrowth and kidney cysts.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (4)   Phenotype Images (4)  
Polymorphisms SNPs within 2kb(1696 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process body morphogenesis, branching involved in ureteric bud morphogenesis...
Component anchored to membrane, anchored to plasma membrane...
Function heparan sulfate proteoglycan binding, protein binding...
External Resources: FuncBase
Expression Literature Summary: (14 records)
Data Summary: Assays (5)    Results (15)    Tissues (13)    Images (3)
Theiler Stages: 11,13,15,16,19,21,22,25
  Assay Type Assays   Results
      RT-PCR 2   3
      RNA in situ 3   12
cDNA source data(128)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(134) Genomic(3) cDNA(128) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000055653
DoTS DT.101176600, DT.87072725
Consensus CDS Project CCDS30125.1
UniGene 22515
DFCI TC1572110, TC1655557
NIA Mouse Gene Index U039382
Entrez Gene 14734
VEGA Gene Model OTTMUSG00000017333
International Mouse Knockout Project Status Gpc3
Protein
domains
InterPro ID Description
IPR001863 Glypican
IPR015501 Glypican-3
IPR019803 Glypican, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:28429 Watanabe K et al., "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney." J Cell Biol 1995 Sep;130(5):1207-18
(Latest) J:154375 Ng A et al., "Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development." Dev Biol 2009 Nov 1;335(1):208-15
All references(31)
Other
accession IDs
MGD-MRK-29057

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory