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Cdkn1c Gene Detail
 Symbol
Name
ID
Cdkn1c
cyclin-dependent kinase inhibitor 1C (P57)
MGI:104564

Nomenclature History
Synonyms CDKI, Kip2, p57Kip2
Genetic Map
Chromosome 7
69.49 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 20)

Sequence Map
Chr7:150644255-150646901 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Cdkn1c ± 2 cM)
Protein SuperFamily: cyclin-dependent kinase inhibitor p57
TreeFam: TF101111
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000037664 Ensembl Gene Model | MGI Sequence Detail 2647 C57BL/6J ± Kb
transcript NM_001161624 RefSeq | MGI Sequence Detail 1952 C57BL/6
polypeptide P49919 UniProt | EBI | MGI Sequence Detail 348 Not Applicable
For the selected sequences
All sequences(28)
Alleles
and
phenotypes 		All alleles(4) : Targeted, knock-out(3) Targeted, other(1)
Homozygous mutants or heterozygotes with a mutant maternal allele have developmental defects including cleft palate, gastrointestinal defects and short limbs. Most mutants die at birth; survivors are growth retarded and have immature reproductive systems.
Associated Human Diseases (2)   Alleles Annotated to Human Diseases (2)  
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell cycle, cell cycle arrest...
Component nucleus
Function cyclin-dependent protein kinase inhibitor activity, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (127 records)
Data Summary: Assays (32)    Results (244)    Tissues (138)    Images (32)
Theiler Stages: 4,9,11,13,15,17,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 2   4
      RT-PCR 18   108
      RNA in situ 9   115
      Immunohistochemistry 1   5
      Northern blot 2   12
cDNA source data(186)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(231) Genomic(24) cDNA(188) Primer pair(14) Other(5) Antibodies(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000037664
DoTS DT.101389917, DT.496075, DT.97359396
Consensus CDS Project CCDS22040.1
UniGene 168789
DFCI TC1572312
NIA Mouse Gene Index U029509
Entrez Gene 12577
International Mouse Knockout Project Status Cdkn1c
Protein
domains
InterPro ID Description
IPR003175 Cyclin-dependent kinase inhibitor
Graphical View of Protein Domain Structure
References
(Earliest) J:10529 Bastian H et al., "A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]" EMBO J 1990 Jun;9(6):1839-52
(Latest) J:156412 Tunster SJ et al., "The imprinted Phlda2 gene regulates extraembryonic energy stores." Mol Cell Biol 2010 Jan;30(1):295-306
All references(161)
Other
accession IDs 		MGD-MRK-25998, MGI:2142098
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory