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Mpz Gene Detail
 Symbol
Name
ID
Mpz
myelin protein zero
MGI:103177


Nomenclature History
Synonyms Mpp, P0
Genetic Map
Chromosome 1
92.4 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 15)

Sequence Map
Chr1:173080842-173091261 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Mpz ± 2 cM)
Protein SuperFamily: myelin P0 protein
TreeFam: TF331728
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021546 VEGA Gene Model | MGI Sequence Detail 10420 C57BL/6J ± Kb
transcript NM_008623 RefSeq | MGI Sequence Detail 1993 C57BL/6
polypeptide P27573 UniProt | EBI | MGI Sequence Detail 248 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes
All alleles(6) : Targeted, knock-out(1) Gene trapped(4) Spontaneous(1)
Associated Human Diseases (3)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(5) SNPs within 2kb(79 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(5)
Process cell-cell junction maintenance
Component integral to membrane, membrane...
Function protein binding
External Resources: MouseFunc
Expression Literature Summary: (16 records)
Data Summary: Assays (1)    Results (3)    Tissues (3)
Theiler Stages: 19,20,28
  Assay Type Assays   Results
      RNA in situ 1   3
cDNA source data(6)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(12) Genomic(3) cDNA(8) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000056569
DoTS DT.101403499, DT.94232526
DFCI TC1574855
NIA Mouse Gene Index U001078
Entrez Gene 17528
VEGA Gene Model OTTMUSG00000021546
International Mouse Knockout Project Status Mpz
Protein
domains
InterPro ID Description
IPR000920 Myelin P0 protein
IPR003596 Immunoglobulin V-set, subgroup
IPR007110 Immunoglobulin-like
IPR013106 Immunoglobulin V-set
IPR013783 Immunoglobulin-like fold
IPR019566 Myelin-PO, C-terminal
IPR019738 Myelin P0 protein, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:10329 Popko B et al., "A novel mutation in myelin-deficient mice results in unstable myelin basic protein gene transcripts." Neuron 1988 May;1(3):221-5
(Latest) J:153219 Grossmann KS et al., "The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development." Proc Natl Acad Sci U S A 2009 Sep 29;106(39):16704-9
All references(76)
Other
accession IDs
MGD-MRK-12531, MGD-MRK-24045

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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