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Wnt11 Gene Detail
 Symbol
Name
ID
Wnt11
wingless-related MMTV integration site 11
MGI:101948


Nomenclature History
Genetic Map
Chromosome 7
48.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 14)

Sequence Map
Chr7:105987355-106002258 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Wnt11 ± 2 cM)
Protein SuperFamily: int-1 transforming protein
TreeFam: TF105310
Sequences
Representative Sequences Length Strain/Species Flank
genomic 22411 NCBI Gene Model | MGI Sequence Detail 14904 C57BL/6J ± Kb
transcript NM_009519 RefSeq | MGI Sequence Detail 2788 -
polypeptide P48615 UniProt | EBI | MGI Sequence Detail 354 Not Applicable
For the selected sequences
All sequences(19)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(1) Targeted, other(2)
Homozygous mutation of this gene results in extensive embryonic lethality and mutants surviving to birth die within the first 2 days of life. The kidneys are small and exhibit delayed development.
Polymorphisms RFLP(1) SNPs within 2kb(110 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell-cell signaling, multicellular organismal development...
Component extracellular region, proteinaceous extracellular matrix...
Function receptor binding, signal transducer activity...
External Resources: FuncBase
Expression Literature Summary: (85 records)
Data Summary: Assays (27)    Results (320)    Tissues (244)    Images (94)
Theiler Stages: 1,2,3,4,5,6,8,9,10,11,12,13,14,15,17,18,19,20,21,22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 12   85
      RNA in situ 13   227
      Immunohistochemistry 1   6
      RNase protection 1   2
cDNA source data(19)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(36) cDNA(21) Primer pair(11) Other(4) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000015957
DoTS DT.40147241, DT.94230101
Consensus CDS Project CCDS21475.1
UniGene 22182
DFCI TC1587635, TC1597606
NIA Mouse Gene Index U008431
Entrez Gene 22411
International Mouse Knockout Project Status Wnt11
Protein
domains
InterPro ID Description
IPR005816 Secreted growth factor Wnt protein
IPR005817 Wnt superfamily
IPR018161 Secreted growth factor Wnt protein, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:21464 Adamson MC et al., "Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a." Genomics 1994 Nov 1;24(1):9-13
(Latest) J:155594 Lu BC et al., "Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis." Nat Genet 2009 Dec;41(12):1295-302
All references(101)
Other
accession IDs
MGD-MRK-18782

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory