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Pou3f4 Gene Detail
 Symbol
Name
ID
Pou3f4
POU domain, class 3, transcription factor 4
MGI:101894


Nomenclature History
Synonyms BRN-4, Brn4, Otf9
Genetic Map
Chromosome X
48.4 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 9)

Sequence Map
ChrX:108009761-108012545 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Pou3f4 ± 2 cM)
Protein SuperFamily: POU domain class 3 transcription factor, brain type
TreeFam: TF316413
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000018379 VEGA Gene Model | MGI Sequence Detail 2785 C57BL/6J ± Kb
transcript NM_008901 RefSeq | MGI Sequence Detail 1086 BALB/c
polypeptide P62515 UniProt | EBI | MGI Sequence Detail 361 Not Applicable
For the selected sequences
All sequences(25)
Alleles
and
phenotypes
All alleles(4) : Targeted, knock-out(1) Targeted, other(1) Spontaneous(1) Radiation induced(1)
Homozygotes for spontaneous, radiation-induced and targeted null mutations exhibit developmental malformations of the inner ear resulting in head-shaking and hearing loss.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (4)  
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(2 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(17)
Process forebrain neuron differentiation, inner ear development...
Component intracellular part, nucleus...
Function DNA binding, sequence-specific DNA binding...
External Resources: MouseFunc
Expression Literature Summary: (39 records)
Data Summary: Assays (9)    Results (213)    Tissues (138)    Images (18)
Theiler Stages: 13,17,19,20,21,22,23,25,28
  Assay Type Assays   Results
      RNA in situ 7   207
      Immunohistochemistry 2   6
cDNA source data(5)
External Resources: GENSAT  GEO 
Molecular
reagents
All nucleic(14) Genomic(3) cDNA(7) Primer pair(2) Other(2) Antibodies(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000056854
DoTS DT.101336841, DT.99857103
DFCI TC1603471, TC1606886, TC1660269
NIA Mouse Gene Index U020145, U020146
Entrez Gene 18994
VEGA Gene Model OTTMUSG00000018379
International Mouse Knockout Project Status Pou3f4
Protein
domains
InterPro ID Description
IPR000327 POU-specific
IPR001356 Homeobox
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding
IPR012287 Homeodomain-related
IPR013847 POU
IPR016362 Transcription factor, homeobox/POU
IPR017970 Homeobox, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:13741 Phillips RJS et al., "New sex-linked mutant - Bhd" Mouse News Lett 1978;58():43-4
(Latest) J:152582 Oliver-Krasinski JM et al., "The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice." J Clin Invest 2009 Jul;119(7):1888-98
All references(63)
Other
accession IDs
MGD-MRK-13084, MGD-MRK-14438, MGD-MRK-1626, MGD-MRK-18721, MGI:98317

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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